Incidence and risk factors for bacterial infection using bortezomib, lenalidomide, and dexamethasone (RVd) in newly diagnosed multiple myeloma

被引：0

作者：

Bici, Anisa ^{[1
,2
]}

Pianko, Matthew J. ^{[3
]}

Nachar, Victoria R. ^{[4
]}

机构：

[1] Michigan Med, Dept Pharm Serv, Ann Arbor, MI USA

[2] Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Rogel Canc Ctr, Dept Internal Med, Div Hematol & Oncol, 1500 East Med Ctr Dr,C365 Med Inn Bldg, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Pharm Serv, Rogel Canc Ctr, Ann Arbor, MI 48109 USA

来源：

LEUKEMIA & LYMPHOMA | 2023年 / 64卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Infection; multiple myeloma; toxicity; bacterial infections; antibiotic prophylaxis; pneumonia; risk factors; ADAPTED THERAPY MSMART; UPDATED MAYO STRATIFICATION; DISEASES SOCIETY; CONSENSUS GUIDELINES; MANAGEMENT; PROPHYLAXIS; PREVENTION; ADULTS; TRANSPLANTATION;

D O I：

10.1080/10428194.2022.2138380

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Infections are an important cause of morbidity and mortality in newly diagnosed multiple myeloma (NDMM), but the real-world risk using modern induction regimens such as bortezomib, lenalidomide, and dexamethasone (RVd) is not well described. We performed a retrospective single-center cohort study to identify infections and risk factors in patients treated with first-line RVd from January 2014 to January 2020 and collected demographic and clinical data. Of 144 patients treated with RVd for NDMM, 21 patients (14.5%) experienced a bacterial infection during induction, of which 8 (5.5%) were grade 3 infections despite a low rate of antibiotic prophylaxis use (12%). Grade 3 neutropenia occurred in 11% of patients, 2% had febrile neutropenia and there were no deaths from infection. On multivariable analysis, age, smoking history, diabetes, antibiotic use in the 60 days preceding the start of RVd, and high-risk cytogenetics were associated with higher risk of bacterial infection.

引用

页码：407 / 414

页数：8

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