Prognostic factors of palatal adenoid cystic carcinoma: A single-center analysis of 85 cases

被引：1
作者：
Gu, Baoxin [1 ,2 ,3 ]
Chi, Yanting [2 ,3 ,4 ]
Wu, Wenjie [1 ,2 ,3 ]
Zhong, Yiwei [1 ,2 ,3 ]
Zhang, Jianyun [2 ,3 ,4 ]
Zhang, Jie [1 ,2 ,3 ]
机构：
[1] Peking Univ Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China
[2] Natl Ctr Stomatol, Beijing, Peoples R China
[3] Natl Clin Res Ctr Oral Dis, Beijing, Peoples R China
[4] Peking Univ Sch & Hosp Stomatol, Dept Oral Pathol, Beijing, Peoples R China
来源：
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY | 2024年 / 9卷 / 02期
关键词：
adenoid cystic carcinoma; margins of excision; palate; prognosis; salivary gland neoplasms; CLINICAL ANALYSIS; NECK DISSECTION; SALIVARY-GLANDS; HEAD; RADIOTHERAPY; EXPERIENCE; INVASION; FEATURES; CANCER;
D O I：
10.1002/lio2.1236
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Objective: The purpose of this retrospective study was to describe the clinicopathological characteristics of primary adenoid cystic carcinoma (ACC) of the palate and to identify the factors affecting prognosis. Methods: The medical records of 85 patients with primary ACC of the palate treated with surgery, with or without adjuvant radiotherapy/chemotherapy, from 2009 to 2019 were reviewed. The relationship of different clinical parameters with locoregional recurrence (LR), distant metastasis (DM), and overall survival (OS) were analyzed. Results: Median follow-up time was 44.6 months. LR and DM rates were 24.7% and 25.9%, respectively, and the 5-year OS and disease-free survival (DFS) rates were 85.9% and 55.1%, respectively. Multivariate analysis showed that positive margins were independently associated with the risk of LR (p < .001). Positive margins (p = .001) and high histological grade (p = .031) were significantly associated with shorter OS. Conclusion: Positive surgical margins are a strong adverse prognostic factor affecting LR and OS in patients with ACC; apart from that, high histopathological grade is an independent predictor of poor OS. Level of Evidence: Level 3 (Prognosis - Cohort study).
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