Cistus incanus: a natural source of antimicrobial metabolites

被引:1
作者
De Filippis, Anna [1 ]
D'Amelia, Vincenzo [2 ,3 ]
Folliero, Veronica [1 ]
Zannella, Carla [1 ]
Franci, Gianluigi [4 ]
Galdiero, Massimiliano [1 ]
Di Loria, Antonio [3 ,5 ]
Laezza, Carmen [6 ]
Monti, Simona Maria [3 ,7 ]
Piccinelli, Anna Lisa [8 ,9 ]
Celano, Rita [8 ,9 ]
Rigano, Maria Manuela [3 ,6 ]
机构
[1] Univ Campania L Vanvitelli, Dept Expt Med, Sect Microbiol & Clin Microbiol, Naples, Italy
[2] CNR, Inst Biosci & BioResources, Portici, Italy
[3] Immunoveg Srl, Portici, Italy
[4] Univ Salerno, Surg & Dent Scuola Med Salernitana, Dept Med, Baronissi, Italy
[5] Univ Naples Federico II, Dept Vet Med & Anim Prod, Naples, Italy
[6] Univ Naples Federico II, Dept Agr Sci, Portici, Italy
[7] CNR, Inst Biostruct & Bioimaging, Naples, Italy
[8] Univ Salerno, Dept Pharm, Fisciano, Italy
[9] NBFC, Natl Biodivers Future Ctr, Palermo, Italy
关键词
Cistus incanus; UHPLC-HRMS/MS; ellagitannins; antiviral and antibacterial activity; RICH PLANT-EXTRACT; ANTIBACTERIAL ACTIVITY; VIRUS ACTIVITY; IN-VITRO; ELLAGITANNINS; L; CYSTUS052;
D O I
10.1080/14786419.2024.2335353
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
The discovery of natural molecules with antimicrobial properties has become an urgent need for the global treatment of bacterium and virus infections. Cistus incanus, a Mediterranean shrub species, represents a valuable source of phytochemicals with an interesting wide-spectrum antimicrobial potential. In this study, we analysed the spectrum of molecules composing a commercial hydroalcoholic extract of C. incanus finding ellagitannins as the most abundant. The effect of the extract and its main constituents (gallic acid, ellagic acid and punicalin) was assessed as co-treatment during viral (HSV-1, HCoV-229E, SARS-CoV-2) and bacterial infection (Staphylococcus aureus and Escherichia coli) of cells and as pre-treatment before virus infections. The results indicated a remarkable antiviral activity of punicalin against SARS-CoV-2 by pre-treating both the viral and the host cells, and a major sensitivity of S. aureus to the C. incanus extract compared to E. coli. The present study highlights broad antimicrobial potential of C. incanus extract.
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页数:14
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共 64 条
[61]   Phytochemical study of Cistus libanotis L. [J].
Venditti, Alessandro ;
Bianco, Armandodoriano ;
Bruno, Maurizio ;
Ben Jemia, Mariem ;
Nicoletti, Marcello .
NATURAL PRODUCT RESEARCH, 2015, 29 (02) :189-192
[62]   Cistus incanus L. commercial products as a good source of polyphenols in human diet [J].
Viapiana, Agnieszka ;
Konopacka, Agnieszka ;
Waleron, Krzysztof ;
Wesolowski, Marek .
INDUSTRIAL CROPS AND PRODUCTS, 2017, 107 :297-304
[63]   Oenological tannins to prevent Botrytis cinerea damage in grapes and musts: Kinetics and electrophoresis characterization of laccase [J].
Vignault, Adeline ;
Gombau, Jordi ;
Jourdes, Michael ;
Moine, Virginie ;
Miquel Canals, Joan ;
Fermaud, Marc ;
Roudet, Jean ;
Zamora, Fernando ;
Teissedre, Pierre-Louis .
FOOD CHEMISTRY, 2020, 316
[64]   A Review on Cistus sp.: Phytochemical and Antimicrobial Activities [J].
Zalegh, Imane ;
Akssira, Mohamed ;
Bourhia, Mohammed ;
Mellouki, Fouad ;
Rhallabi, Naima ;
Salamatullah, Ahmad Mohammad ;
Alkaltham, Mohammed Saeed ;
Alyahya, Heba Khalil ;
Mhand, Rajaa Ait .
PLANTS-BASEL, 2021, 10 (06)