Evaluation of Ki67, Bax, Bcl-2 and KIT in canine cutaneous mast cell tumours and their relationship with histopathology and prognosis

被引:0
作者
Danyer, Isil Aytemiz [1 ,2 ]
Gurel, Aydin [2 ]
机构
[1] Minist Agr & Forestry, Ankara, Turkiye
[2] Univ Istanbul Cerrahpasa, Fac Vet, Dept Pathol, 34500 Buyukcekmece, Istanbul, Turkiye
关键词
canine cutaneous mast cell tumour; histopathological grading; Ki67; Bax; Bcl-2; KIT; MITOTIC INDEX; C-KIT; EXPRESSION; SURVIVAL; PROLIFERATION; DOGS; ASSOCIATIONS; MARKERS; CD117; KI-67;
D O I
10.1556/004.2023.00867
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Canine cutaneous mast cell tumours (CCMCTs) are common in dogs and exhibit many unpredictable behaviors. This study aimed to encourage pathology laboratories in developing countries to routinely assess prognosis by applying commonly used histopathological grading systems and immunohistochemistry (IHC) markers. We performed histological grading according to both the Patnaik and Kiupel systems, determined the mitotic count (MC) and carried out IHC for the detection of Ki67, Bax, Bcl-2 and KIT in 54 CCMCT cases. MC was associated with both grading systems in terms of survival following diagnosis and prognostic factors differed among cases categorized by the cut-off value of 5. KIT patterns were associated with grading systems and MC. The cohort with pattern II had a lower survival rate than those with patterns I and III. Ki67 was associated with survival when evaluated over the cut-off value of 0.018. Bax expression was associated with both grading systems. Median survival time was longer in patients with lower Bax expression level. Immunohistochemical detection of KIT, Ki67 and Bax improves histopathology in predicting the prognosis. If IHC is unavailable, reports regarding MC and values from both grading systems are the most effective, convenient and costeffective way to provide the most reliable prognostic data and guidance for the clinicians.
引用
收藏
页码:183 / 192
页数:10
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