The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

被引：184

作者：

Alexander, Stephen P. H. ^{[1
]}

Christopoulos, Arthur ^{[2
,3
]}

Davenport, Anthony P. ^{[4
]}

Kelly, Eamonn ^{[5
]}

Mathie, Alistair A. ^{[6
]}

Peters, John A. ^{[7
]}

Veale, Emma L. ^{[8
,9
]}

Armstrong, Jane F. ^{[10
]}

Faccenda, Elena ^{[10
]}

Harding, Simon D. ^{[10
]}

Davies, Jamie A. ^{[10
]}

Abbracchio, Maria Pia ^{[11
]}

Abraham, George ^{[4
]}

Agoulnik, Alexander ^{[12
]}

Alexander, Wayne ^{[13
]}

Al-hosaini, Khaled ^{[14
]}

Back, Magnus ^{[15
]}

Baker, Jillian G. ^{[1
]}

Barnes, Nicholas M. ^{[16
]}

Bathgate, Ross ^{[17
]}

Beaulieu, Jean-Martin ^{[18
]}

Beck-Sickinger, Annette G. ^{[19
]}

Behrens, Maik ^{[20
]}

Bernstein, Kenneth E. ^{[21
]}

Bettler, Bernhard ^{[22
]}

Birdsall, Nigel J. M. ^{[23
]}

Blaho, Victoria ^{[24
]}

Boulay, Francois ^{[25
]}

Bousquet, Corinne ^{[26
]}

Brauner-Osborne, Hans ^{[27
]}

Burnstock, Geoffrey ^{[28
]}

Calo, Girolamo ^{[29
]}

Castano, Justo P. ^{[30
]}

Catt, Kevin J. ^{[31
]}

Ceruti, Stefania ^{[11
]}

Chazot, Paul ^{[32
]}

Chiang, Nan ^{[33
]}

Chini, Bice ^{[34
]}

Chun, Jerold ^{[35
]}

Cianciulli, Antonia ^{[36
]}

Civelli, Olivier ^{[37
]}

Clapp, Lucie H. ^{[28
]}

Couture, Rejean ^{[38
]}

Cox, Helen M. ^{[39
]}

Csaba, Zsolt ^{[40
]}

Dahlgren, Claes ^{[41
]}

Dent, Gordon ^{[42
]}

Douglas, Steven D. ^{[43
]}

Dournaud, Pascal ^{[40
]}

Eguchi, Satoru ^{[44
]}

机构：

[1] Univ Nottingham, Med Sch, Sch Life Sci, Nottingham NG7 2UH, England

[2] Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia

[3] Monash Univ, Dept Pharmacol, Parkville, Vic 3052, Australia

[4] Univ Cambridge, Clin Pharmacol Unit, Cambridge CB2 0QQ, England

[5] Univ Bristol, Sch Physiol Pharmacol & Neurosci, Bristol BS8 1TD, Avon, England

[6] Suffolk Univ, Sch Engn Arts Sci & Technol, Ipswich IP4 1QJ, Suffolk, England

[7] Univ Dundee, Ninewells Hosp & Med Sch, Med Educ Inst, Neurosci Div, Dundee DD1 9SY, Scotland

[8] Univ Greenwich, Medway Sch Pharm, Anson Bldg,Cent Ave, Chatham ME4 4TB, Kent, England

[9] Univ Kent Medway, Medway Sch Pharm, Anson Bldg,Cent Ave, Chatham ME4 4TB, Kent, England

[10] Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh EH8 9XD, Midlothian, Scotland

[11] Univ Milan, Milan, Italy

[12] Florida Int Univ, Miami, FL 33199 USA

[13] Emory Univ, Atlanta, GA 30322 USA

[14] King Saud Univ, Riyadh, Saudi Arabia

[15] Karolinska Univ Hosp, Stockholm, Sweden

[16] Univ Birmingham, Birmingham, W Midlands, England

[17] Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia

[18] Univ Toronto, Toronto, ON, Canada

[19] Univ Leipzig, Leipzig, Germany

[20] Tech Univ Munich, Freising Weihenstephan, Germany

[21] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

[22] Univ Basel, Basel, Switzerland

[23] Francis Crick Inst, London, England

[24] Sanford Burnham Prebys Med Discovery Inst, La Jolla, CA USA

[25] Univ Grenoble Alpes, Grenoble, France

[26] INSERM, Toulouse, France

[27] Univ Copenhagen, Copenhagen, Denmark

[28] UCL, London, England

[29] Univ Padua, Padua, Italy

[30] Univ Cordoba, Cordoba, Spain

[31] NIH, Bldg 10, Bethesda, MD 20892 USA

[32] Univ Durham, Durham, England

[33] Harvard Univ, Boston, MA 02115 USA

[34] Univ Milano Bicocca, Vedano Al Lambro, Italy

[35] Univ Calif San Diego, La Jolla, CA 92093 USA

[36] Univ Bari, Bari, Italy

[37] Univ Calif Irvine, Irvine, CA USA

[38] Univ Montreal, Montreal, PQ, Canada

[39] Kings Coll London, London, England

[40] INSERM, Paris, France

[41] Univ Gothenburg, Gothenburg, Sweden

[42] Keele Univ, Keele, Staffs, England

[43] Univ Penn, Philadelphia, PA 19104 USA

[44] Temple Univ, Philadelphia, PA 19122 USA

[45] Univ Sherbrooke, Sherbrooke, PQ, Canada

[46] Univ Iowa, Iowa City, IA USA

[47] Labcorp Drug Dev, Somerset, NJ USA

[48] St Petersburg State Univ, St Petersburg, Russia

[49] Univ Otago, Dunedin, New Zealand

[50] MG Consulting Co, Basel, Switzerland

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2023年 / 180卷

关键词：

D O I：

10.1111/bph.16177

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at . G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

引用

页码：S23 / S144

页数：122