Bilateral Spontaneous Supraspinatus Tendon Rupture Under Prolonged BRAF/MEK Targeting Treatment in a Melanoma Patient

被引：0

作者：

Bafaloukos, Dimitrios ^{[1
]}

Gazouli, Ioanna ^{[1
]}

Koutserimpas, Christos ^{[2
,3
]}

Skarlos, Pantelis D. ^{[4
]}

Samonis, George ^{[1
,5
]}

机构：

[1] Metropolitan Hosp, Dept Med Oncol, Athens, Greece

[2] 251 Air Force Gen Hosp, Dept Orthoped & Traumatol, Athens, Greece

[3] Natl & Kapodistrian Univ Athens, Dept Anat, Athens, Greece

[4] Metropolitan Hosp, Dept Radiat Oncol, Athens, Greece

[5] Univ Crete, Dept Med, Iraklion, Greece

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 12期

关键词：

rotator cuff tear; side effects; tendon rupture; trametinib; braf/mek targeting; braf mutation; melanoma; ACHILLES-TENDON; CORTICOSTEROID INJECTIONS; CIPROFLOXACIN; TENDINOPATHY;

D O I：

10.7759/cureus.50567

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The B-Raf proto-oncogene, serine/threonine kinase (BRAF)/ mitogen-activated protein kinase kinase (MEK) targeting agents have become the treatment of choice for BRAF-mutated melanoma during the last decade. However, it is possible that some long-term adverse events of these drugs have not yet been reported. A case of bilateral spontaneous, non-traumatic, supraspinatus tendon rupture in a 65-year-old Caucasian male suffering metastatic melanoma under prolonged and successful combination treatment with dabrafenib plus trametinib is presented. These damages could not be attributed to some other probable cause. The ruptured tendons were promptly restored arthroscopically. Oncologists should remain vigilant for the early detection of potential side effects of BRAF/MEK targeting agents that have not been systematically recorded yet but may appear and affect patients in the long run.

引用

页数：4

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