The gut-liver axis in hepatobiliary diseases

被引：3

作者：

Ichikawa, Masataka ^{[1
]}

Okada, Haruka ^{[1
]}

Nakamoto, Nobuhiro ^{[1
]}

Taniki, Nobuhito ^{[1
]}

Chu, Po-Sung ^{[1
]}

Kanai, Takanori ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, Tokyo 1608582, Japan

来源：

INFLAMMATION AND REGENERATION | 2024年 / 44卷 / 01期

关键词：

Intestinal bacteria; Gut-liver axis; Leaky gut; Primary sclerosing cholangitis; Fecal microbiota transplantation; Bacteriophage; PRIMARY SCLEROSING CHOLANGITIS; CHAIN FATTY-ACIDS; FECAL MICROBIOTA TRANSPLANTATION; TUMOR-NECROSIS-FACTOR; BILE-ACIDS; BACTERIAL TRANSLOCATION; INTESTINAL INFLAMMATION; HEPATOCELLULAR-CARCINOMA; URSODEOXYCHOLIC ACID; CLINICAL-TRIAL;

D O I：

10.1186/s41232-023-00315-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent advances in the analysis of intestinal bacteria have led to reports of variations in intestinal bacterial levels among hepatobiliary diseases. The mechanisms behind the changes in intestinal bacteria in various hepatobiliary diseases include the abnormal composition of intestinal bacteria, weakening of the intestinal barrier, and bacterial translocation outside the intestinal tract, along with their metabolites, but many aspects remain unresolved. Further research employing clinical studies and animal models is expected to clarify the direct relationship between intestinal bacteria and hepatobiliary diseases and to validate the utility of intestinal bacteria as a diagnostic biomarker and potential therapeutic target. This review summarizes the involvement of the microbiota in the pathogenesis of hepatobiliary diseases via the gut-liver axis.

引用

页数：16

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