The gut-liver axis in hepatobiliary diseases

被引：3

作者：

Ichikawa, Masataka ^{[1
]}

Okada, Haruka ^{[1
]}

Nakamoto, Nobuhiro ^{[1
]}

Taniki, Nobuhito ^{[1
]}

Chu, Po-Sung ^{[1
]}

Kanai, Takanori ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, Tokyo 1608582, Japan

来源：

INFLAMMATION AND REGENERATION | 2024年 / 44卷 / 01期

关键词：

Intestinal bacteria; Gut-liver axis; Leaky gut; Primary sclerosing cholangitis; Fecal microbiota transplantation; Bacteriophage; PRIMARY SCLEROSING CHOLANGITIS; CHAIN FATTY-ACIDS; FECAL MICROBIOTA TRANSPLANTATION; TUMOR-NECROSIS-FACTOR; BILE-ACIDS; BACTERIAL TRANSLOCATION; INTESTINAL INFLAMMATION; HEPATOCELLULAR-CARCINOMA; URSODEOXYCHOLIC ACID; CLINICAL-TRIAL;

D O I：

10.1186/s41232-023-00315-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent advances in the analysis of intestinal bacteria have led to reports of variations in intestinal bacterial levels among hepatobiliary diseases. The mechanisms behind the changes in intestinal bacteria in various hepatobiliary diseases include the abnormal composition of intestinal bacteria, weakening of the intestinal barrier, and bacterial translocation outside the intestinal tract, along with their metabolites, but many aspects remain unresolved. Further research employing clinical studies and animal models is expected to clarify the direct relationship between intestinal bacteria and hepatobiliary diseases and to validate the utility of intestinal bacteria as a diagnostic biomarker and potential therapeutic target. This review summarizes the involvement of the microbiota in the pathogenesis of hepatobiliary diseases via the gut-liver axis.

引用

页数：16

共 153 条

[1] Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial [J].

Allegretti, Jessica R. ;

Kassam, Zain ;

Carrellas, Madeline ;

Mullish, Benjamin H. ;

Marchesi, Julian R. ;

Pechlivanis, Alexandros ;

Smith, Mark ;

Gerardin, Ylaine ;

Timberlake, Sonia ;

Pratt, Daniel S. ;

Korzenik, Joshua R. .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2019, 114 (07) :1071-1079

[2] The Pathophysiology of Farnesoid X Receptor (FXR) in the GI Tract: Inflammation, Barrier Function and Innate Immunity [J].

Anderson, Kemp M. ;

Gayer, Christopher P. .

CELLS, 2021, 10 (11)

[3] Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation [J].

Arpaia, Nicholas ;

Campbell, Clarissa ;

Fan, Xiying ;

Dikiy, Stanislav ;

van der Veeken, Joris ;

deRoos, Paul ;

Liu, Hui ;

Cross, Justin R. ;

Pfeffer, Klaus ;

Coffer, Paul J. ;

Rudensky, Alexander Y. .

NATURE, 2013, 504 (7480) :451-+

[4] Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in a murine model of PSC [J].

Awoniyi, Muyiwa ;

Wang, Jeremy ;

Ngo, Billy ;

Meadows, Vik ;

Tam, Jason ;

Viswanathan, Amba ;

Lai, Yunjia ;

Montgomery, Stephanie ;

Farmer, Morgan ;

Kummen, Martin ;

Thingholm, Louise ;

Schramm, Christoph ;

Bang, Corinna ;

Franke, Andre ;

Lu, Kun ;

Zhou, Huiping ;

Bajaj, Jasmohan S. ;

Hylemon, Phillip B. ;

Ting, Jenny ;

Popov, Yury, V ;

Hov, Johannes Roksund ;

Francis, Heather L. ;

Sartor, Ryan Balfour .

GUT, 2023, 72 (04) :671-685

[5] Mechanisms of disease: The effect of infections on susceptibility to autoimmune and allergic diseases [J].

Bach, JF .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (12) :911-920

[6] Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells [J].

Bachem, Annabel ;

Makhlouf, Christina ;

Binger, Katrina J. ;

de Souza, David P. ;

Tull, Deidra ;

Hochheiser, Katharina ;

Whitney, Paul G. ;

Fernandez-Ruiz, Daniel ;

Dahling, Sabrina ;

Kastemuller, Wolfgang ;

Jonsson, Johanna ;

Gressier, Elise ;

Lew, Andrew M. ;

Perdomo, Carolina ;

Kupz, Andreas ;

Figgett, William ;

Mackay, Fabienne ;

Oleshansky, Moshe ;

Russ, Brendan E. ;

Parish, Ian A. ;

Kallies, Axel ;

McConville, Malcolm J. ;

Tumer, Stephen J. ;

Gebhardt, Thomas ;

Bedoui, Sammy .

IMMUNITY, 2019, 51 (02) :285-+

[7] Fecal Microbial Transplant Capsules Are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo-Controlled Trial [J].

Bajaj, Jasmohan S. ;

Salzman, Nita H. ;

Acharya, Chathur ;

Sterling, Richard K. ;

White, Melanie B. ;

Gavis, Edith A. ;

Fagan, Andrew ;

Hayward, Michael ;

Holtz, Mary L. ;

Matherly, Scott ;

Lee, Hannah M. ;

Osman, Majdi ;

Siddiqui, Mohammad S. ;

Fuchs, Michael ;

Puri, Puneet ;

Sikaroodi, Masoumeh ;

Gillevet, Patrick M. .

HEPATOLOGY, 2019, 70 (05) :1690-1703

[8] Fecal Microbiota Transplant From a Rational Stool Donor Improves Hepatic Encephalopathy: A Randomized Clinical Trial [J].

Bajaj, Jasmohan S. ;

Kassam, Zain ;

Fagan, Andrew ;

Gavis, Edith A. ;

Liu, Eric ;

Cox, I. Jane ;

Kheradman, Raffi ;

Heuman, Douglas ;

Wang, Jessica ;

Gurry, Thomas ;

Williams, Roger ;

Sikaroodi, Masoumeh ;

Fuchs, Michael ;

Alm, Eric ;

John, Binu ;

Thacker, Leroy R. ;

Riva, Antonio ;

Smith, Mark ;

Taylor-Robinson, Simon D. ;

Gillevet, Patrick M. .

HEPATOLOGY, 2017, 66 (06) :1727-1738

[9] The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota [J].

Balmer, Maria L. ;

Slack, Emma ;

de Gottardi, Andrea ;

Lawson, Melissa A. E. ;

Hapfelmeier, Siegfried ;

Miele, Luca ;

Grieco, Antonio ;

Van Vlierberghe, Hans ;

Fahrner, Rene ;

Patuto, Nicola ;

Bernsmeier, Christine ;

Ronchi, Francesca ;

Wyss, Madeleine ;

Stroka, Deborah ;

Dickgreber, Nina ;

Heim, Markus H. ;

Mccoy, Kathy D. ;

Macpherson, Andrew J. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (237)

[10] Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver [J].

Bertocchi, Alice ;

Carloni, Sara ;

Ravenda, Paola Simona ;

Bertalot, Giovanni ;

Spadoni, Ilaria ;

Lo Cascio, Antonino ;

Gandini, Sara ;

Lizier, Michela ;

Braga, Daniele ;

Asnicar, Francesco ;

Segata, Nicola ;

Klaver, Chris ;

Brescia, Paola ;

Rossi, Elio ;

Anselmo, Achille ;

Guglietta, Silvia ;

Maroli, Annalisa ;

Spaggiari, Paola ;

Tarazona, Noelia ;

Cervantes, Andres ;

Marsoni, Silvia ;

Lazzari, Luca ;

Jodice, Maria Giovanna ;

Luise, Chiara ;

Erreni, Marco ;

Pece, Salvatore ;

Di Fiore, Pier Paolo ;

Viale, Giuseppe ;

Spinelli, Antonino ;

Pozzi, Chiara ;

Penna, Giuseppe ;

Rescigno, Maria .

CANCER CELL, 2021, 39 (05) :708-+

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