Effect of Nonsurgical Periodontal Treatment on Salivary and Plasma Superoxide Dismutase Levels of Patients Suffering from Periodontitis

被引:7
作者
Veljovic, Tanja [1 ]
Djuric, Milanko [1 ,2 ]
Mirnic, Jelena [1 ]
Gusic, Ivana [1 ,2 ]
Maletin, Aleksandra [1 ]
Ivic, Stojan [1 ,2 ]
Stojilkovic, Marija [1 ]
Brkic, Snezana [1 ,3 ]
机构
[1] Univ Novi Sad, Fac Med, Dept Dent Med, Novi Sad 21000, Serbia
[2] Univ Novi Sad, Fac Med, Dept Dent Med, Dent Clin Vojvodina, Novi Sad 21000, Serbia
[3] Univ Novi Sad, Fac Med, Clin Ctr Vojvodina, Clin Infect Dis, Novi Sad 21000, Serbia
关键词
superoxide dismutase; oxidative stress; periodontal disease; plasma; treatment; GINGIVAL CREVICULAR FLUID; TOTAL ANTIOXIDANT CAPACITY; LIPID-PEROXIDATION LEVELS; TOTAL OXIDANT STATUS; OXIDATIVE STRESS; DISEASE; SERUM; MARKERS;
D O I
10.3390/jcm12206688
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Antioxidant capacity is frequently measured by evaluating superoxide dismutase (SOD) concentration in body fluids. The aim of this study was to compare SOD concentrations in the saliva and plasma of patients with periodontitis to those measured in a group of patients with healthy periodontium, as well as to evaluate the influence of nonsurgical periodontal therapy on salivary and plasma SOD in periodontitis patients. For this purpose, 40 systemically healthy patients aged 30-70 years who had at least 20 teeth were recruited, 20 of whom had periodontitis, and 20 served as healthy periodontitis-free controls. In all participants, periodontal status was assessed via the plaque index (PI), gingival index (GI), papilla bleeding index (PIB), probing depth (PD), and clinical attachment level (CAL), and the SOD concentration in both saliva and plasma was determined by conducting a commercial immunoenzymatic ELISA test. In periodontitis patients, periodontal indices and saliva and blood samples were taken at the beginning of the study, as well as 3 months after periodontal therapy, while in the control group, these data were gathered at the beginning of the study only. SOD values in the saliva of patients with periodontitis (0.244 U/mu L) were statistically significantly higher compared with patients with healthy periodontium (0.017 U/mu L). Moreover, periodontal therapy led to a statistically significant decrease in this marker in the saliva of patients with periodontitis (p = 0.023), which was comparable with that measured in the control group. On the other hand, no statistically significant differences were noted in plasma SOD values either between the two groups or at follow-up compared with baseline in the group with periodontitis. These findings suggest that the elevated salivary SOD in patients with periodontal disease may represent a mechanism of tissue protection against oxidative stress that occurs in response to periodontal disease.
引用
收藏
页数:11
相关论文
共 57 条
[1]   Analysis of superoxide dismutase activity levels in gingiva and gingival crevicular fluid in patients with chronic periodontitis and periodontally healthy controls [J].
Akalin, FA ;
Toklu, E ;
Renda, N .
JOURNAL OF CLINICAL PERIODONTOLOGY, 2005, 32 (03) :238-243
[2]   Superoxide dismutase activity in gingiva in type-2 diabetes mellitus patients with chronic periodontitis [J].
Akalin, Ferda Alev ;
Isiksal, Eda ;
Baltacioglu, Esra ;
Renda, Nurten ;
Karabulut, Erdem .
ARCHIVES OF ORAL BIOLOGY, 2008, 53 (01) :44-52
[3]   Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis [J].
Akalin, Ferda Alev ;
Baltacioglu, Esra ;
Alver, Ahmet ;
Karabulut, Erdem .
JOURNAL OF CLINICAL PERIODONTOLOGY, 2007, 34 (07) :558-565
[4]   Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis [J].
Allen, Edith M. ;
Matthews, John B. ;
O' Halloran, Domhnall J. ;
Griffiths, Helen R. ;
Chapple, Iain L. .
JOURNAL OF CLINICAL PERIODONTOLOGY, 2011, 38 (10) :894-901
[5]   Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children's Saliva [J].
Araujo, Heitor Ceolin ;
Nakamune, Ana Claudia Melo Stevanato ;
Garcia, Wilson Galhego ;
Pessan, Juliano Pelim ;
Antoniali, Cristina .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2020, 2020 (2020)
[6]   Effect of Endodontic Treatment on Serum Glutathione (GSH) Levels in Patients with Chronic Apical Periodontitis: A Clinical Pilot Study [J].
Bains, Rhythm ;
Tikku, Aseem P. ;
Chandra, Anil ;
Ali, Wahid ;
Verma, Promila .
JOURNAL OF ADVANCED ORAL RESEARCH, 2021, 12 (01) :81-85
[7]  
Biju Thomas, 2014, Indian J Dent Res, V25, P613, DOI 10.4103/0970-9290.147105
[8]   Local and systemic total antioxidant capacity in periodontitis and health [J].
Brock, GR ;
Butterworth, CJ ;
Matthews, JB ;
Chapple, ILC .
JOURNAL OF CLINICAL PERIODONTOLOGY, 2004, 31 (07) :515-521
[9]   Total antioxidant capacity and antioxidant enzymes in serum, saliva, and gingival crevicular fluid of preeclamptic women with and without Periodontal disease [J].
Canakci, Varol ;
Yildirim, Abdulkadir ;
Canakci, Cenk Fatih ;
Eltas, Abubekir ;
Cicek, Yasin ;
Canakci, Hurneyra .
JOURNAL OF PERIODONTOLOGY, 2007, 78 (08) :1602-1611
[10]   Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way [J].
Carneiro Sczepanik, Fabio Sa ;
Grossi, Marcio Lima ;
Casati, Marcio ;
Goldberg, Michael ;
Glogauer, Michael ;
Fine, Noah ;
Tenenbaum, Howard C. .
PERIODONTOLOGY 2000, 2020, 84 (01) :45-68