Role of the viral polymerase during adaptation of influenza A viruses to new hosts

被引:6
作者
Gilbertson, Brad [1 ]
Duncan, Melanie [2 ]
Subbarao, Kanta [1 ,2 ]
机构
[1] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic, Australia
[2] WHO, Collaborating Ctr Reference & Res Influenza, Victorian Infect Dis Reference Lab Peter Doherty I, Melbourne, Vic, Australia
关键词
AMINO-ACID CHANGES; RNA-POLYMERASE; NUCLEAR IMPORT; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; HUMAN INFECTION; PANDEMIC H1N1; PA PROTEIN; ENHANCES VIRULENCE; PB2;
D O I
10.1016/j.coviro.2023.101363
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
As a group, influenza-A viruses (IAV) infect a wide range of animal hosts, however, they are constrained to infecting selected host species by species-specific interactions between the host and virus, that are required for efficient replication of the viral RNA genome. When IAV cross the species barrier, they acquire mutations in the viral genome to enable interactions with the new host factors, or to compensate for their loss. The viral polymerase genes polymerase basic 1, polymerase basic 2, and polymerase-acidic are important sites of host adaptation. In this review, we discuss why the viral polymerase is so vital to the process of host adaptation, look at some of the known viral mutations, and host factors involved in adaptation, particularly of avian IAV to mammalian hosts.
引用
收藏
页数:14
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