Epigenetics regulation of prostate cancer: Biomarker and therapeutic potential

被引：16
作者：
Ragavi, Ravindran [1 ]
Muthukumaran, Panneerselvam [1 ]
Nandagopal, Srividhya [1 ]
Ahirwar, Dinesh Kumar [2 ]
Tomo, Sojit [1 ]
Misra, Sanjeev [3 ]
Guerriero, Giulia [4 ]
Shukla, Kamla Kant [1 ]
机构：
[1] All India Inst Med Sci, Dept Biochem, Jodhpur, Rajasthan, India
[2] Indian Inst Technol Jodhpur, Dept Biosci & Bioengn, Jodhpur, Rajasthan, India
[3] Atal Bihari Vajpayee Med Univ, Lucknow, Uttar Pradesh, India
[4] Univ Naples Federico II, Dept Biol, Comparat Endocrinol Lab, Naples, Italy
来源：
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | 2023年 / 41卷 / 08期
关键词：
Biomarker; Diagnostics; Epigenetics; DNA methylation; MicroRNA; lncRNA; Prognostics; Therapeutics CaP; PROMOTER HYPERMETHYLATION; PROGNOSTIC BIOMARKERS; RECENT SCENARIO; METHYLATION; EXPRESSION; GROWTH; RECURRENCE; HEPARANASE; DIAGNOSIS; BREAST;
D O I：
10.1016/j.urolonc.2023.03.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Prostate cancer (CaP) is the second leading cause of cancer death and displays a broad range of clinical behavior from relatively indolent to aggressive metastatic disease. The etiology of most cases of CaP is not understood completely, which makes it imperative to search for the molecular basis of CaP and markers for early diagnosis. Epigenetic modifications, including changes in DNA methylation patterns, histone modifications, miRNAs, and lncRNAs are key drivers of prostate tumorigenesis. These epigenetic defects might be due to deregulated expression of the epigenetic machinery, affecting the expression of several important genes like GSTP1, RASSF1, CDKN2, RARRES1, IGFBP3, RARB, most important epigenetic gene alterations and their variations as a diagnostic marker and target for therapeutic intervention of CaP in the future. Characterization of epigenetic changes involved in CaP is obscure and adequate validation studies are still required to corroborate the present results that would be the impending future of transforming basic research settings into clinical practice. & COPY; 2023 Elsevier Inc. All rights reserved.
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收藏
页码：340 / 353
页数：14
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