Spinal fusion for single-level SPECT/CT positive lumbar degenerative disc disease: the SPINUS I study

Introduction and purposeWith current imaging modalities and diagnostic tests, identifying pain generators in patients with non-specific chronic low back pain (CLBP) is difficult. There is growing evidence of the effectiveness of SPECT/CT examination in diagnosing the source of pain in the spine. The study aims to investigate the effect of posterior interbody fusion on a single-level SPECT/CT positive lumbar degenerative disc disease (DDD).Material and methodsThis is a prospective study of patients with chronic low back pain (CLBP) operated on for a single-level SPECT/CT positive DDD. Primary outcomes were changes in visual analogue scale (VAS) scores and the Oswestry Disability Index (ODI). Secondary outcomes were complications, return to work, satisfaction and willingness to re-undergo surgery.ResultsDuring a 3-year period, 38 patients underwent single-level fusion surgery. The mean preoperative VAS score of 8.4 (& PLUSMN; 1.1) decreased to 3.2 (& PLUSMN; 2.5, p < 0.001) and the mean preoperative ODI of 51.5 (& PLUSMN; 7.3) improved to 20.7 (& PLUSMN; 14.68, p < 0.001) at a 2-year follow-up. A minimum clinically important difference (30% reduction in VAS and ODI) was achieved in 84.2% of patients. Some 71% of patients were satisfied with the surgery results and 89.4% would undergo surgery again. There were four complications, and two patients underwent revision surgery. Some 82.9% of patients returned to work.ConclusionFusion for one-level SPECT/CT positive lumbar DDD resulted in substantial clinical improvement and satisfaction with surgical treatment. Therefore, SPECT/CT imaging could be useful in assessing patients with CLBP, especially those with unclear MRI findings.