Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

被引:85
作者
Kunnumakkara, Ajaikumar B. [1 ]
Hegde, Mangala [1 ]
Parama, Dey [1 ]
Girisa, Sosmitha [1 ]
Kumar, Aviral [1 ]
Daimary, Uzini Devi [1 ]
Garodia, Prachi [3 ]
Yenisetti, Sarat Chandra [4 ]
V. Oommen, Oommen [5 ]
Aggarwal, Bharat B. [2 ]
机构
[1] Indian Inst Technol Guwahati, Dept Biosci & Bioengn, Gauhati 781039, Assam, India
[2] Inflammat Res Ctr, San Diego, CA 92109 USA
[3] Integrat Res Ctr, Miami, FL 33125 USA
[4] Nagaland Univ Cent, Dept Zool, Drosophila Neurobiol Lab, Lumami 798627, Nagaland, India
[5] Univ Kerala, Dept Computat Biol & Bioinformat, Thiruvananthapuram 695581, Kerala, India
关键词
turmeric; curcumin; chronic diseases; natural compounds; clinical trials; QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIAL; TYPE-2; DIABETES-MELLITUS; FATTY LIVER-DISEASE; HIGHLY-BIOAVAILABLE CURCUMIN; PLACEBO-CONTROLLED TRIAL; CHRONIC KIDNEY-DISEASE; ORAL LICHEN-PLANUS; CHRONIC PULMONARY COMPLICATIONS; OXIDANT-ANTIOXIDANT BALANCE;
D O I
10.1021/acsptsci.2c00012
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Turmeric (Curcuma longa) has been used for thousands of years for the prevention and treatment of various chronic diseases. Curcumin is just one of >200 ingredients in turmeric. Almost 7000 scientific papers on turmeric and almost 20,000 on curcumin have been published in PubMed. Scientific reports based on cell culture or animal studies are often not reproducible in humans. Therefore, human clinical trials are the best indicators for the prevention and treatment of a disease using a given agent/drug. Herein, we conducted an extensive literature survey on PubMed and Scopus following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The keywords "turmeric and clinical trials" and "curcumin and clinical trials" were considered for data mining. A total of 148 references were found to be relevant for the key term "turmeric and clinical trials", of which 70 were common in both PubMed and Scopus, 44 were unique to PubMed, and 34 were unique to Scopus. Similarly, for the search term "curcumin and clinical trials", 440 references were found to be relevant, of which 70 were unique to PubMed, 110 were unique to Scopus, and 260 were common to both databases. These studies show that the golden spice has enormous health and medicinal benefits for humans. This Review will extract and summarize the lessons learned about turmeric and curcumin in the prevention and treatment of chronic diseases based on clinical trials.
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收藏
页码:447 / 518
页数:72
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