Regulation of Adenine Nucleotide Metabolism by Adenylate Kinase Isozymes: Physiological Roles and Diseases

被引：18

作者：

Fujisawa, Koichi ^{[1
]}

机构：

[1] Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Environm Oncol, 1-1 Iseigaoka,Yahatanishi Ku, Kitakyushu 8078555, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 06期

基金：

日本学术振兴会;

关键词：

adenine nucleotides; adenylate kinase; energy metabolism; ATP; enzyme; HEMOLYTIC-ANEMIA; HEREDITARY-DEFICIENCY; PROTEOMIC ANALYSIS; ENERGY-METABOLISM; IDENTIFICATION; EXPRESSION; PROTEINS; EXOSOMES; CANCER; GENES;

D O I：

10.3390/ijms24065561

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adenylate kinase (AK) regulates adenine nucleotide metabolism and catalyzes the ATP + AMP 2ADP reaction in a wide range of organisms and bacteria. AKs regulate adenine nucleotide ratios in different intracellular compartments and maintain the homeostasis of the intracellular nucleotide metabolism necessary for growth, differentiation, and motility. To date, nine isozymes have been identified and their functions have been analyzed. Moreover, the dynamics of the intracellular energy metabolism, diseases caused by AK mutations, the relationship with carcinogenesis, and circadian rhythms have recently been reported. This article summarizes the current knowledge regarding the physiological roles of AK isozymes in different diseases. In particular, this review focused on the symptoms caused by mutated AK isozymes in humans and phenotypic changes arising from altered gene expression in animal models. The future analysis of intracellular, extracellular, and intercellular energy metabolism with a focus on AK will aid in a wide range of new therapeutic approaches for various diseases, including cancer, lifestyle-related diseases, and aging.

引用

页数：16

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