Synthesis of Aryl-methylene Ethers through Pd(0)-Catalyzed Coupling between Hydrobenzoxazoles and Dichloromethane

被引：3

作者：

Wang, Yinpeng ^{[1
]}

Zhao, Mingming ^{[1
]}

Peng, Jingke ^{[1
]}

Zheng, Hongxia ^{[1
]}

Xiong, Heng-Ying ^{[1
]}

Zhang, Guangwu ^{[1
]}

机构：

[1] Henan Univ, Coll Chem & Chem Engn, Kaifeng 475004, Peoples R China

来源：

ORGANIC LETTERS | 2023年

基金：

中国国家自然科学基金;

关键词：

OXIDATIVE-ADDITION; PALLADIUM; KETIMINES; CARBENE; HALIDES; ACTIVATION; ANNULATION; COMPLEXES;

D O I：

10.1021/acs.orglett.3c00190

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using dichloromethane (DCM) as the C1 feedstock, the first Pd(0)-catalyzed synthesis of aryl-methylene ether motifs from hydrobenzoxazoles (hydrothiazoles) has been reported. This protocol has exhibited an ample substrate scope (38 examples) and wide functional group tolerance. Aryl-methylene ether adducts have been successfully engaged in coupling with isocyanate to provide bis-iminoisoindolinones. In this reaction, DCM has served as a twofold electrophile for reaction with hydrobenzoxazoles via double C-Cl bond cleavage.

引用

页码：1458 / 1463

页数：6