The multidisciplinary management of cholangiocarcinoma

被引：14

作者：

Ohaegbulam, Kim C. ^{[1
]}

Koethe, Yilun ^{[2
]}

Fung, Alice ^{[3
]}

Mayo, Skye C. ^{[4
]}

Grossberg, Aaron J. ^{[1
]}

Chen, Emerson Y. ^{[5
]}

Sharzehi, Kaveh ^{[6
]}

Kardosh, Adel ^{[5
]}

Farsad, Khashayar ^{[2
]}

Rocha, Flavio G. ^{[4
]}

Thomas, Charles R. ^{[1
,7
]}

Nabavizadeh, Nima ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Radiat Med, Portland, OR 97201 USA

[2] Oregon Hlth & Sci Univ, Dept Intervent Radiol, Portland, OR 97201 USA

[3] Oregon Hlth & Sci Univ, Dept Diagnost Radiol, 3181 Sw Sam Jackson Pk Rd, Portland, OR 97201 USA

[4] Oregon Hlth & Sci Univ, Dept Surg Oncol, Portland, OR 97201 USA

[5] Oregon Hlth & Sci Univ, Div Hematol Med Oncol, Portland, OR 97201 USA

[6] Oregon Hlth & Sci Univ, Div Gastroenterol & Hepatol, Portland, OR 97201 USA

[7] Dartmouth Sch Med, Dept Radiat Oncol, Hanover, NH USA

来源：

CANCER | 2023年 / 129卷 / 02期

关键词：

biliary disease; cholangiocarcinoma; multidisciplinary; primary liver malignancy; radiotherapy; BILIARY-TRACT CANCER; STEREOTACTIC BODY RADIOTHERAPY; EXTERNAL-BEAM RADIOTHERAPY; CIRCULATING TUMOR-CELLS; DOSE-RATE BRACHYTHERAPY; PRIMARY LIVER CANCERS; INTRAHEPATIC CHOLANGIOCARCINOMA; BILE-DUCT; RADIATION-THERAPY; EXTRAHEPATIC CHOLANGIOCARCINOMA;

D O I：

10.1002/cncr.34541

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cholangiocarcinoma is a lethal malignancy of the biliary epithelium that can arise anywhere along the biliary tract. Surgical resection confers the greatest likelihood of long-term survivability. However, its insidious onset, difficult diagnostics, and resultant advanced presentation render the majority of patients unresectable, highlighting the importance of early detection with novel biomarkers. Developing liver-directed therapies and emerging targeted therapeutics may offer improved survivability for patients with unresectable or advanced disease. In this article, the authors review the current multidisciplinary standards of care in resectable and unresectable cholangiocarcinoma, with an emphasis on novel biomarkers for early detection and nonsurgical locoregional therapy options.

引用

页码：184 / 214

页数：31

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