Autologous platelet-rich plasma (APRP) in diabetes foot disease: a meta-analysis

被引：3

作者：

Ruiz-Munoz, Maria ^{[1
]}

Martinez-Barrios, Francisco-Javier ^{[1
]}

Fernandez-Torres, Raul ^{[1
]}

Lopezosa-Reca, Eva ^{[1
]}

Marchena-Rodriguez, Ana ^{[1
]}

机构：

[1] Univ Malaga, Fac Hlth Sci, Dept Nursing & Podiatry, Arquitecto Francisco Penalosa 3,Ampliac Campus Tea, Malaga 29071, Spain

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2024年 / 38卷 / 02期

关键词：

Autologous growth factors; Diabetic foot disease; Meta-analysis; Ulcer treatment; Randomised controlled trials; Platelet-rich plasma; CONTROLLED-TRIAL; GEL; ULCERS; LEUKOCYTE;

D O I：

10.1016/j.jdiacomp.2024.108690

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: This study will explore the effectiveness of autologous platelet-rich plasma in the treatment of diabetic foot disease compared to conventional treatments, based on the ulcer healing rate. Methods: The electronic databases of PubMed, EMBASE, and WOS internet were searched. Evaluated outcome rate of complete ulcer healing. Statistical analysis was performed with RevMan 5.0 software and SPSS 25.0. Results: Eleven RCTs with 828 patients were included in this study. The meta -analysis showed a higher complete ulcer healing rate (OR = 3.69, 95 % CI 2.62 to 5.20, P < 0.01, I-2 = 0 %) in growth factors based in autologous platelech-rich plasma (aPRP) group compared with control. Mixed evidence was seen for publication bias, but analyses by using the trim -and -fill method did not appreciably alter results. Conclusion: Autologous platelet-rich plasma can improve the complete healing rate of the ulcer compared to current conventional treatments in diabetic foot ulcer patients.

引用

页数：9

共 56 条

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