PhI(OAc) 2 -Promoted Regioselective Cycloaddition of N -Aminopyridinium Ylides with Electron-Deficient Alkenes

被引：1
作者：
Wang, Junlei [1 ]
Chen, Guiling [1 ]
Shi, Chengcheng
Xie, Qinglin
Gao, Guocheng [1 ]
Li, Yanan [2 ,3 ]
Du, Haijun [1 ]
Cai, Xiaohua
Li, Hongqing [1 ]
Huang, Binbin [2 ,3 ]
机构：
[1] Guizhou Minzu Univ, Guiyang 550025, Peoples R China
[2] Beijing Normal Univ, Zhuhai 519087, Peoples R China
[3] Beijing Normal Univ, Coll Arts & Sci, Zhuhai 519087, Peoples R China
来源：
SYNLETT | 2024年 / 35卷 / 13期
关键词：
regioselective; cycloaddition; N; -aminopyridinium; alkenes; HETEROARYLATION; DISCOVERY; INHIBITORS; REAGENTS; ACCESS; POTENT;
D O I：
10.1055/a-2216-4594
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we report a regioselective cycloaddition strategy of N-aminopyridinium ylides with electron-deficient alkenes, in the presence of a hypervalent iodine reagent, PhI(OAc)(2). A variety of multifunctionalized pyrazolo[1,5-a]pyridine architectures were smoothly afforded by the reactions of pyridine-, quinoline-, and isoquinoline-based N-ylides with diverse alkenes with or without a halogen atom adjacent to the electron-withdrawing group (EWG) under facile conditions.
引用
收藏
页码：1551 / 1556
页数：6
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