Navigating the boundaries between metabolism and epigenetics in trypanosomes

被引:0
作者
Menezes, Ana Paula [1 ,2 ]
Murillo, Ana Milena [3 ]
de Castro, Camila Gachet [1 ,2 ]
Bellini, Natalia Karla [1 ,2 ]
Tosi, Luiz Ricardo Orsini [4 ]
Thiemann, Otavio Henrique [5 ]
Elias, Maria Carolina [1 ,2 ]
Silber, Ariel Mariano [3 ]
da Cunha, Julia Pinheiro Chagas [1 ,2 ]
机构
[1] Inst Butantan, Lab Ciclo Celular, Sao Paulo, SP, Brazil
[2] Inst Butantan, Ctr Toxinas Resposta Imune & Sinalizacao Celular C, Sao Paulo, Brazil
[3] Univ Sao Paulo, Dept Parasitol, Lab Bioquim Tryps LabTryps, Sao Paulo, SP, Brazil
[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, SP, Brazil
[5] Univ Sao Paulo, Inst Fis Sao Carlos, Sao Carlos, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
NICOTINAMIDE-ADENINE DINUCLEOTIDE; POLYCISTRONIC TRANSCRIPTION UNITS; LIFE-CYCLE; ACETYL-COA; POSTTRANSLATIONAL MODIFICATIONS; HISTONE ACETYLATION; II TRANSCRIPTION; REDOX STATE; BASE-J; CRUZI;
D O I
10.1016/j.pt.2023.05.010
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Epigenetic marks enable cells to acquire new biological features that favor their adaptation to environmental changes. These marks are chemical modifications on chromatin-associated proteins and nucleic acids that lead to changes in the chromatin landscape and may eventually affect gene expression. The chemical tags of these epigenetic marks are comprised of intermediate cellular metabo-lites. The number of discovered associations between metabolism and epige-netics has increased, revealing how environment influences gene regulation and phenotype diversity. This connection is relevant to all organisms but under -appreciated in digenetic parasites, which must adapt to different environments as they progress through their life cycles. This review speculates and proposes associations between epigenetics and metabolism in trypanosomes, which are protozoan parasites that cause human and livestock diseases.
引用
收藏
页码:682 / 695
页数:14
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