EVALUATION OF COLIA1 GENE RS1107946 POLYMORPHISM IN RELATION TO BONE MINERAL DENSITY AND FRACTURE RISK IN SLOVAK POSTMENOPAUSAL WOMEN

被引:0
作者
Boronova, Iveta [1 ]
Mathia, Matus [1 ]
Macekova, Sona [1 ]
Bernasovska, Jarmila [1 ]
Gal'ova, Jana [1 ]
机构
[1] Univ Presov, Fac Humanities & Nat Sci, Dept Biol, Ul 17 November 1, Presov 08001, Slovakia
关键词
COLIA1; gene; rs1107946; polymorphism; osteoporosis; postmenopausal women; fracture risk; UPSTREAM REGULATORY REGION; INTRON; POLYMORPHISMS; COL1A1; HAPLOTYPES; PROMOTER; METAANALYSIS; ASSOCIATION; QUALITY;
D O I
10.21101/cejph.a7329
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objectives: The aim of the study was the evaluation of the rs1107946 polymorphism of the COLIA1 gene impact on bone mineral density and fracture risk in Slovak postmenopausal women.Methods: One hundred and twenty-seven postmenopausal Slovak women with a diagnosis of osteopenia/osteoporosis were genotyped for rs1107946 polymorphism of the COLIA1 gene. Clinical and anthropometric data were obtained. DNA isolation was performed using a standard protocol. Genetic analyses of the rs1107946 polymorphism of the COLIA1 gene were performed by the TaqMan SNP genotyping assays.Results: The study confirmed a statistically significant relationship using an association analysis between the rs1107946 polymorphism of the COLIA1 gene genotypes and body weight of the Slovak postmenopausal women with osteopenia/osteoporosis (p = 0.03). The study revealed a significant association of the risk T allele of the rs1107946 polymorphism of the COLIA1 gene with osteoporotic fractures (p = 0.038). The odds ratio confirmed 2.060 times higher risk of osteoporotic fractures in Slovak postmenopausal women with the presence of risk T allele of the rs1107946 COLIA1 gene polymorphism (OR = 2.060; 95% CI: 1.024-4.144).Conclusion: The results of this study revealed an association of T allele of the rs1107946 COLIA1 gene polymorphism with osteoporotic fractures in Slovak postmenopausal women with osteopenia/osteoporosis and suggest that the rs1107946 polymorphism of the COLIA1 gene may be a molecular biomarker usable in the management of osteoporosis.
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页码:25 / 29
页数:5
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