m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis

被引：12

作者：

Jiang, Xiaohan ^{[1
]}

Jin, Ziyao ^{[2
]}

Yang, Yuzhong ^{[1
]}

Zheng, Xiang ^{[1
]}

Chen, Shaohua ^{[3
]}

Wang, Shuaijie ^{[1
]}

Zhang, Xuemei ^{[4
]}

Qu, Nanfang ^{[5
]}

机构：

[1] Guilin Med Univ, Affiliated Hosp, Dept Pathol, Guilin, Peoples R China

[2] Zhejiang Univ, Stomatol Hosp, Sch Stomatol, Key Lab Oral Biomed Res Zhejiang Prov,Sch Med, Hangzhou, Peoples R China

[3] Guangxi Med Univ, Liuzhou Peoples Hosp, Dept Breast & Thyroid Surg, Liuzhou, Peoples R China

[4] Guangxi Med Univ, Liuzhou Peoples Hosp, Dept Pathol, Liuzhou, Peoples R China

[5] Guilin Med Univ, Affiliated Hosp, Dept Gastroenterol, Guilin, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2023年 / 13卷

基金：

中国国家自然科学基金;

关键词：

colorectal cancer; N6-methyladenosine; RNA modification; proliferation; tumorigenesis; MESSENGER-RNA METHYLATION; PENTOSE-PHOSPHATE PATHWAY; N6-METHYLADENOSINE MODIFICATION; AEROBIC GLYCOLYSIS; M(6)A MODIFICATION; GENE-EXPRESSION; NUCLEAR-RNA; PROGRESSION; PROMOTES; DEMETHYLASE;

D O I：

10.3389/fonc.2023.1162300

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

N6-methyladenosine (m6A) is the most pervasive RNA modification in eukaryotic cells. The dynamic and reversible m6A modification of RNA plays a critical role in the occurrence and progression of tumors by regulating RNA metabolism, including translocation, mRNA stability or decay, pre-mRNA splicing, and lncRNA processing. Numerous studies have shown that m6A modification is involved in the development of various cancers. This review aims to summarize the significant role of m6A modification in the proliferation and tumorigenesis of CRC, as well as the potential of modulating m6A modification for tumor treatment. These findings may offer new therapeutic strategies for clinical implementation of m6A modification in CRC in the near future.

引用

页数：14

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