Cracking the case of m7G modification in human tRNAs

被引：0

作者：

Barraud, Pierre ^{[1
]}

Tisne, Carine ^{[1
]}

机构：

[1] Univ Paris Cite, Inst Physico Chem Biol IBPC, Ctr Natl Rech Sci, Microbial Gene Express Unit, Paris, France

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2023年 / 30卷 / 3期

关键词：

DATABASE;

D O I：

10.1038/s41594-023-00937-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The RNA methyltransferase (MTase) METTL1 catalyzes N-7-methylguanosine (m(7)G) modification at position 46 in human transfer RNAs (tRNAs). Its dysregulation drives tumorigenesis in many cancer types. Two papers now reveal the structural basis of this tRNA maturation event.

引用

页码：242 / 243

页数：2

共 15 条

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