A multicenter retrospective analysis of patients with nasopharyngeal carcinoma treated in IMRT era from a nonendemic population: Turkish Society for Radiation Oncology Head and Neck Cancer Group Study (TROD 01-001)

被引：1

作者：

Yildirim, Halil Cumhur ^{[1
]}

Kupik, Gulnihan Eren ^{[2
]}

Mustafayev, Teuta Zoto ^{[3
]}

Berber, Tanju ^{[4
]}

Yavuz, Berrin ^{[5
]}

Cetinayak, Oguz ^{[6
]}

Akagunduz, Ozlem ^{[7
]}

Bicakci, Beyhan Ceylaner ^{[8
]}

Arslan, Suheyla Aytac ^{[9
]}

Soykut, Ela Delikgoz ^{[10
]}

Gundog, Mete ^{[11
]}

Figen, Metin ^{[12
]}

Teke, Fatma ^{[13
]}

Canyilmaz, Emine ^{[14
]}

Birgi, Sumerya Duru ^{[15
]}

Duzova, Mursel ^{[16
]}

Igdem, Sefik ^{[17
]}

Abakay, Candan Demiroz ^{[18
]}

Atasoy, Beste ^{[19
]}

Kaydihan, Nuri ^{[20
]}

Parvizi, Murtaza ^{[21
]}

Uslu, Gonca Hanedan ^{[22
]}

Saginc, Halil ^{[23
]}

Akman, Fadime ^{[6
]}

Ozyar, Enis ^{[3
]}

机构：

[1] Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Dept Radiat Oncol, Istanbul, Turkiye

[2] Mugla Sitki Kocman Univ, Fac Med, Dept Radiat Oncol, Mugla, Turkiye

[3] Acibadem Univ, Fac Med, Dept Radiat Oncol, Istanbul, Turkiye

[4] Prof Dr Cemil Tascioglu City Hosp, Dept Radiat Oncol, Istanbul, Turkiye

[5] Necmettin Erbakan Univ, Meram Fac Med, Dept Radiat Oncol, Konya, Turkiye

[6] Dokuz Eylul Univ, Fac Med, Dept Radiat Oncol, Izmir, Turkiye

[7] Ege Univ, Fac Med, Dept Radiat Oncol, Izmir, Turkiye

[8] Kartal Dr Lutfi Kirdar City Hosp, Dept Radiat Oncol, Istanbul, Turkiye

[9] Ankara City Hosp, Dept Radiat Oncol, Ankara, Turkiye

[10] Samsun Educ & Res Hosp, Dept Radiat Oncol, Samsun, Turkiye

[11] Erciyes Univ, Fac Med, Dept Radiat Oncol, Kayseri, Turkiye

[12] Sisli Hamidiye Etfal Educ & Res Hosp, Dept Radiat Oncol, Istanbul, Turkiye

[13] Dicle Univ, Fac Med, Dept Radiat Oncol, Diyarbakir, Turkiye

[14] Karadeniz Tech Univ, Fac Med, Dept Radiat Oncol, Trabzon, Turkiye

[15] Ankara Univ, Fac Med, Dept Radiat Oncol, Ankara, Turkiye

[16] Selcuk Univ, Fac Med, Dept Radiat Oncol, Konya, Turkiye

[17] Istanbul Bilim Univ, Gayrettepe Florence Nightingale Hosp, Dept Radiat Oncol, Istanbul, Turkiye

[18] Bursa Uludag Univ, Fac Med, Dept Radiat Oncol, Bursa, Turkiye

[19] Marmara Univ, Fac Med, Dept Radiat Oncol, Istanbul, Turkiye

[20] Istanbul Bahcelievler Mem Hosp, Dept Radiat Oncol, Istanbul, Turkiye

[21] Manisa City Hosp, Dept Radiat Oncol, Manisa, Turkiye

[22] Trabzon Kanuni Educ & Res Hosp, Dept Radiat Oncol, Trabzon, Turkiye

[23] Pamukkale Univ, Fac Med, Dept Radiat Oncol, Denizli, Turkiye

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2023年 / 45卷 / 05期

关键词：

chemoradiotherapy; EBV-DNA; intensity-modulated radiotherapy; nasopharyngeal carcinoma; nonendemic; INTENSITY-MODULATED RADIOTHERAPY; AJCC/UICC STAGING SYSTEM; CONCURRENT CHEMORADIOTHERAPY; 8TH EDITION; CHEMOTHERAPY; DNA; VALIDATION; OUTCOMES; TRIALS; AREAS;

D O I：

10.1002/hed.27333

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

BackgroundWe aimed to evaluate patients with nasopharyngeal carcinoma (NPC) in a nonendemic population. MethodsIn a national, retrospective, multicenteric study, 563 patients treated with intensity modulated radiotherapy at 22 centers between 2015 and 2020 were analyzed. ResultsMedian age was 48 (9-83), age distribution was bimodal, 74.1% were male, and 78.7% were stage III-IVA. Keratinizing and undifferentiated carcinoma rates were 3.9% and 81.2%. Patients were treated with concomitant chemoradiotherapy (48.9%), or radiotherapy combined with induction chemotherapy (25%) or adjuvant chemotherapy (19.5%). After 34 (6-78) months follow-up, 8.2% locoregional and 8% distant relapse were observed. Three-year overall survival was 89.5% and was lower in patients with age >= 50, male sex, keratinizing histology, T4, N3 and advanced stage (III-IVA). ConclusionsPatients with NPC in Turkey have mixed clinical features of both east and west. Survival outcomes are comparable to other reported series; however, the rate of distant metastases seems to be lower.

引用

页码：1194 / 1205

页数：12

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