Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders

被引：45

作者：

Cohen, Jessica ^{[1
]}

Mathew, Annette ^{[1
]}

Dourvetakis, Kirk D. ^{[1
]}

Sanchez-Guerrero, Estella ^{[1
]}

Pangeni, Rajendra P. ^{[1
]}

Gurusamy, Narasimman ^{[2
]}

Aenlle, Kristina K. ^{[1
,3
]}

Ravindran, Geeta ^{[4
]}

Twahir, Assma ^{[1
]}

Isler, Dylan ^{[1
]}

Sosa-Garcia, Sara Rukmini ^{[1
]}

Llizo, Axel ^{[1
]}

Bested, Alison C. ^{[1
]}

Theoharides, Theoharis C. ^{[1
,5
]}

Klimas, Nancy G. ^{[1
,3
]}

Kempuraj, Duraisamy ^{[1
]}

机构：

[1] Nova Southeastern Univ, Inst Neuroimmune Med, Dr Kiran C Patel Coll Osteopath Med, Ft Lauderdale, FL 33328 USA

[2] Nova Southeastern Univ, Barry & Judy Silverman Coll Pharm, Dept Pharmaceut Sci, Ft Lauderdale, FL 33328 USA

[3] Miami Vet Affairs Healthcare Syst, Miami VA Geriatr Res Educ & Clin Ctr GRECC, Miami, FL 33125 USA

[4] Nova Southeastern Univ, Cell Therapy Inst, Dr Kiran C Patel Coll Allopath Med, Ft Lauderdale, FL 33328 USA

[5] Tufts Univ, Sch Med, Dept Immunol, Lab Mol Immunopharmacol & Drug Discovery, Boston, MA 02111 USA

来源：

CELLS | 2024年 / 13卷 / 06期

基金：

英国科研创新办公室;

关键词：

Alzheimer's disease; Gulf War Illness; human induced pluripotent stem cells; myalgic encephalomyelitis/chronic fatigue syndrome; neuroinflammation; Parkinson's disease; traumatic brain injury; AMYOTROPHIC-LATERAL-SCLEROSIS; FATIGUE SYNDROME/MYALGIC ENCEPHALOMYELITIS; TRAUMATIC BRAIN-INJURY; GULF-WAR ILLNESS; MAST-CELLS; DISEASE; BIOMARKERS; ACTIVATION; ALS; MICROGLIA;

D O I：

10.3390/cells13060511

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neuroinflammatory and neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), traumatic brain injury (TBI) and Amyotrophic lateral sclerosis (ALS) are chronic major health disorders. The exact mechanism of the neuroimmune dysfunctions of these disease pathogeneses is currently not clearly understood. These disorders show dysregulated neuroimmune and inflammatory responses, including activation of neurons, glial cells, and neurovascular unit damage associated with excessive release of proinflammatory cytokines, chemokines, neurotoxic mediators, and infiltration of peripheral immune cells into the brain, as well as entry of inflammatory mediators through damaged neurovascular endothelial cells, blood-brain barrier and tight junction proteins. Activation of glial cells and immune cells leads to the release of many inflammatory and neurotoxic molecules that cause neuroinflammation and neurodegeneration. Gulf War Illness (GWI) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are chronic disorders that are also associated with neuroimmune dysfunctions. Currently, there are no effective disease-modifying therapeutic options available for these diseases. Human induced pluripotent stem cell (iPSC)-derived neurons, astrocytes, microglia, endothelial cells and pericytes are currently used for many disease models for drug discovery. This review highlights certain recent trends in neuroinflammatory responses and iPSC-derived brain cell applications in neuroinflammatory disorders.

引用

页数：28

共 261 条

[1] Induced Pluripotent Stem Cells (iPSCs)-Roles in Regenerative Therapies, Disease Modelling and Drug Screening [J].