Objective: The main goal of the study was to find whether pumpkin (Cucurbita pepo) extract has any preventive or antioxidant properties against acute uranyl acetate (UA)-induced reproductive cytotoxicity. Material and Methods: Four groups each, including 10 adult male rats, were randomly assigned. (GI): the control group was given 1 ml of purified water orally for 30 days. (GII): Rats were given orally, a single dose of 150 mg/kg b.w. UA (GIII): Rats consumed 40 mg/kg b.w. of pumpkin seed extract (PSE) orally every day for 30 days. (GIV): Rats received a single dose (150 mg/kg b.w.) of UA plus a daily oral dose of PSE (40 mg/kg b.w.) for 30 days. Animal sacrifice was used for oxidative stress and histopathological study. Results: Showed significantly (p >= 0.001) elevated malondialdehyde levels in the GII group (6.19 +/- 0.4), while GIII and GIV showed no significant differences. Glutathione peroxidase showed a significant (p >= 0.001) decrease (2.55 +/- 0.2) in the GII group, while in groups (GIII and GIV), it showed a significant (p >= 0.001) increase (4.61 +/- 0.16, 4.28 +/- 0.032), respectively. The histopathological study for GII groups showed sloughing of epithelial cells lining the seminiferous tubules with a decrease in the number of spermatozoa in some tubules. Many sections revealed hyperplasia of the epithelial cells lining the seminiferous tubules with necrosis. The GIII and GIV groups showed normal histological structures with an increase in spermatogenesis in the testes and epididymis tissues. Conclusion: We concluded that UA causes oxidative stress and histopathological alterations in the rat reproductive system. Pumpkin extract plays a role in improving the activity of the reproductive system.
机构:
King Abdulaziz Univ KAU, Fac Sci, Biochem Dept, Jeddah, Saudi Arabia
King Abdulaziz Univ, King Fahd Med Res Ctr, Expt Biochem Unit, Jeddah, Saudi ArabiaKing Abdulaziz Univ KAU, Fac Sci, Biochem Dept, Jeddah, Saudi Arabia
Mosaoa, Rami M. M.
Kumosani, Taha A. A.
论文数: 0引用数: 0
h-index: 0
机构:
King Abdulaziz Univ KAU, Fac Sci, Biochem Dept, Jeddah, Saudi Arabia
King Abdulaziz Univ, King Fahd Med Res Ctr, Expt Biochem Unit, Jeddah, Saudi Arabia
King Abdulaziz Univ, Prod Bioprod Ind Applicat Res Grp, Jeddah, Saudi ArabiaKing Abdulaziz Univ KAU, Fac Sci, Biochem Dept, Jeddah, Saudi Arabia
Kumosani, Taha A. A.
Yaghmoor, Soonham S. S.
论文数: 0引用数: 0
h-index: 0
机构:
King Abdulaziz Univ, King Fahd Med Res Ctr, Expt Biochem Unit, Jeddah, Saudi Arabia
King Abdulaziz Univ, Prod Bioprod Ind Applicat Res Grp, Jeddah, Saudi ArabiaKing Abdulaziz Univ KAU, Fac Sci, Biochem Dept, Jeddah, Saudi Arabia
Yaghmoor, Soonham S. S.
Rihan, Shaimaa
论文数: 0引用数: 0
h-index: 0
机构:
Ain Shams Univ, Fac Sci, Biochem Dept, Cairo, EgyptKing Abdulaziz Univ KAU, Fac Sci, Biochem Dept, Jeddah, Saudi Arabia
Rihan, Shaimaa
Moselhy, Said S. S.
论文数: 0引用数: 0
h-index: 0
机构:
Ain Shams Univ, Fac Sci, Biochem Dept, Cairo, EgyptKing Abdulaziz Univ KAU, Fac Sci, Biochem Dept, Jeddah, Saudi Arabia
机构:
Kafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, EgyptKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
Shipa, Ahmed M. E.
Kahilo, Khaled A.
论文数: 0引用数: 0
h-index: 0
机构:
Kafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, EgyptKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
Kahilo, Khaled A.
Elshazly, Samir A.
论文数: 0引用数: 0
h-index: 0
机构:
Kafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, EgyptKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
Elshazly, Samir A.
Taher, Ehab S.
论文数: 0引用数: 0
h-index: 0
机构:
Zarqa Univ, Fac Dent, Dept Basic Med & Dent Sci, Zarqa 13110, JordanKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
Taher, Ehab S.
Nasr, Nasr E.
论文数: 0引用数: 0
h-index: 0
机构:
Kafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, EgyptKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
Nasr, Nasr E.
Alotaibi, Badriyah S.
论文数: 0引用数: 0
h-index: 0
机构:
Princess Nourah Bint Abdulrahman Univ, Coll Pharm, Dept Pharmaceut Sci, POB 84428, Riyadh 11671, Saudi ArabiaKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
Alotaibi, Badriyah S.
Almadaly, Essam A.
论文数: 0引用数: 0
h-index: 0
机构:
Kafrelsheikh Univ, Fac Vet Med, Dept Theriogenol, Kafrelsheikh 33516, EgyptKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
Almadaly, Essam A.
Assas, Mona
论文数: 0引用数: 0
h-index: 0
机构:
Kafrelsheikh Univ, Fac Aquat & Fisheries Sci, Fish Proc & Biotechnol Dept, Kafrelsheikh 33516, EgyptKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
Assas, Mona
Abdo, Walied
论文数: 0引用数: 0
h-index: 0
机构:
Kafrelsheikh Univ, Fac Vet Med, Dept Vet Pathol, Kafr Al Sheikh 33516, EgyptKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
Abdo, Walied
Abouzed, Tarek K.
论文数: 0引用数: 0
h-index: 0
机构:
Kafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
Univ Misrata, Fac Med, Biochem Dept, Misrata, LibyaKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
Abouzed, Tarek K.
Salem, Abdulati Elsanusi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Misrata, Fac Med, Biochem Dept, Misrata, LibyaKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
Salem, Abdulati Elsanusi
Kirci, Damla
论文数: 0引用数: 0
h-index: 0
机构:
Selcuk Univ, Fac Pharm, Dept Pharmacognosy, Konya, TurkiyeKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
Kirci, Damla
El-Seedi, Hesham R.
论文数: 0引用数: 0
h-index: 0
机构:
Islamic Univ Madinah, Fac Sci, Dept Chem, Madinah 42351, Saudi ArabiaKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
El-Seedi, Hesham R.
Refaey, Mohamed S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sadat City, Fac Pharm, Dept Pharmacognosy, Sadat City 32897, EgyptKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
Refaey, Mohamed S.
Rizk, Nermin I.
论文数: 0引用数: 0
h-index: 0
机构:
Menoufia Univ, Fac Med, Med Physiol Dept, Menoufia, EgyptKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
Rizk, Nermin I.
Shukry, Mustafa
论文数: 0引用数: 0
h-index: 0
机构:
Kafrelsheikh Univ, Fac Vet Med, Dept Physiol, Kafrelsheikh, EgyptKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt
Shukry, Mustafa
Dorghamm, Doaa A.
论文数: 0引用数: 0
h-index: 0
机构:
Kafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, EgyptKafrelsheikh Univ, Fac Vet Med, Dept Biochem, Kafrelsheikh 33516, Egypt