Association between maternal hypertension and infant neurodevelopment in extremely preterm infants

被引：1

作者：

Abdelmageed, Wael A. ^{[1
]}

Lapointe, Anie ^{[2
]}

Brown, Richard ^{[3
]}

Gorgos, Andreea ^{[4
]}

Luu, Thuy Mai ^{[5
]}

Beltempo, Marc ^{[6
]}

Altit, Gabriel ^{[6
]}

Dayan, Natalie ^{[3
]}

机构：

[1] McGill Univ, Hlth Ctr, Dept Med, Div Expt Med, Montreal, PQ, Canada

[2] Sainte Justine Univ Hosp Ctr, Dept Paediat, Div Neonatol, Montreal, PQ, Canada

[3] McGill Univ, Hlth Ctr, Res Inst, Montreal, PQ, Canada

[4] McGill Univ, Montreal Childrens Hosp, Neonatal Follow Up, Montreal, PQ, Canada

[5] Sainte Justine Univ Hosp Ctr, Dept Paediat, Neonatal Follow Up, Montreal, PQ, Canada

[6] McGill Univ, Montreal Childrens Hosp, Dept Pediat, Div Neonatol,Hlth Ctr, Montreal, PQ, Canada

来源：

JOURNAL OF PERINATOLOGY | 2024年 / 44卷 / 04期

关键词：

CHILDREN BORN; NECROTIZING ENTEROCOLITIS; LESS-THAN-29; WEEKS; BIRTH-WEIGHT; PREGNANCY; OUTCOMES; MOTHERS; DISORDERS; PREECLAMPSIA; IMPACT;

D O I：

10.1038/s41372-024-01886-7

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

ObjectiveTo examine the association between maternal hypertension during pregnancy and neurodevelopmental impairment (NDI) at 24 months post-menstrual age in extremely preterm infants.Study designUsing data from two tertiary neonatal units (2011-2017) for infants born at 23 + 0 to 28 + 6 weeks, we investigated outcomes of NDI related to maternal hypertension and small-for-gestational-age (SGA) status.ResultsOf 1019 pre-term infants, 647 had complete data and were included in the analysis. Ninety-six (15%) had maternal hypertension exposure; 25 (4%) were also SGA. Infants with maternal hypertension showed a higher odds of any NDI (aOR: 2.29, 95% CI = 1.36-3.87) and significant NDI (aOR: 2.01, 95% CI = 1.02-3.95). The combination of hypertension and SGA further elevated this risk (aOR for any NDI: 4.88, 95% CI = 1.80-13.22; significant NDI: 6.91, 95% CI = 2.50-19.12).ConclusionMaternal hypertension during pregnancy elevates the risk of NDI in extremely preterm infants, more so when combined with SGA.

引用

页码：539 / 547

页数：9

共 58 条

[1] Bayley scales of infant and toddler development, third edition. [J].

Albers, Craig A. ;

Grieve, Adam J. .

JOURNAL OF PSYCHOEDUCATIONAL ASSESSMENT, 2007, 25 (02) :180-190

[2] Neurodevelopmental Outcomes of Infants Born at <29 Weeks of Gestation Admitted to Canadian Neonatal Intensive Care Units Based on Location of Birth [J].

Amer, Reem ;

Moddemann, Diane ;

Seshia, Mary ;

Alvaro, Ruben ;

Synnes, Anne ;

Lee, Kyong-Soon ;

Lee, Shoo K. ;

Shah, Prakesh S. .

JOURNAL OF PEDIATRICS, 2018, 196 :31-+

[3]

Aucott Susan W, 2004, J Perinatol, V24, P435

[4] The role of magnesium sulfate (MgSO4) in fetal neuroprotection [J].

Bachnas, Muhammad Adrianes ;

Akbar, Muhammad Ilham Aldika ;

Dachlan, Erry Gumilar ;

Dekker, Gustaaf .

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2021, 34 (06) :966-978

[5] Outcome of small-for-gestational age and appropriate-for-gestational age infants born before 27 weeks of gestation [J].

Bardin, C ;

Zelkowitz, P ;

Papageorgiou, A .

PEDIATRICS, 1997, 100 (02) :E4

[6] NEONATAL NECROTIZING ENTEROCOLITIS - THERAPEUTIC DECISIONS BASED UPON CLINICAL STAGING [J].

BELL, MJ ;

TERNBERG, JL ;

FEIGIN, RD ;

KEATING, JP ;

MARSHALL, R ;

BARTON, L ;

BROTHERTON, T .

ANNALS OF SURGERY, 1978, 187 (01) :1-7

[7] Early and late onset pre-eclampsia and small for gestational age risk in subsequent pregnancies [J].

Bernardes, Thomas P. ;

Mol, Ben W. ;

Ravelli, Anita C. J. ;

van den Berg, Paul ;

Boezen, H. Marike ;

Groen, Henk .

PLOS ONE, 2020, 15 (03)

[8] Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control [J].

Biagas, Katherine, V ;

Hinton, Veronica J. ;

Hasbani, Natalie R. ;

Luckett, Peter M. ;

Wypij, David ;

Nadkarni, Vinay M. ;

Agus, Michael S. D. ;

Agus, Michael ;

Nadkarni, Vinay ;

Srinivasan, Vijay ;

Biagas, Katherine ;

Mourani, Peter ;

Chima, Ranjit ;

Thomas, Neal ;

Li, Simon ;

Pinto, Alan ;

Newth, Christopher ;

Hassinger, Amanda ;

Bysani, Kris ;

Rehder, Kyle ;

Faustino, Vince ;

Kandil, Sarah ;

Hirshberg, Eliotte ;

Wintergerst, Kupper ;

Schwarz, Adam ;

Bagdure, Dayanand ;

Marsillio, Lauren ;

Cvijanovich, Natalie ;

Pham, Nga ;

Quasney, Michael ;

Flori, Heidi ;

Federman, Myke ;

Nett, Sholeen ;

Pinto, Neethi ;

Viteri, Shirley ;

Schneider, James ;

Medar, Shivanand ;

Sapru, Anil ;

McQuillen, Patrick ;

Babbitt, Christopher ;

Lin, John ;

Jouvet, Philippe ;

Yanay, Ofer ;

Allen, Christine ;

Fackler, James ;

Luckett, Peter ;

Rozen, Thomas .

JOURNAL OF PEDIATRICS, 2020, 218 :57-+

[9] Born Too Soon: The global epidemiology of 15 million preterm births [J].

Blencowe, Hannah ;

Cousens, Simon ;

Chou, Doris ;

Oestergaard, Mikkel ;

Say, Lale ;

Moller, Ann-Beth ;

Kinney, Mary ;

Lawn, Joy .

REPRODUCTIVE HEALTH, 2013, 10

[10] Elevated maternal C-reactive protein and autism in a national birth cohort [J].

Brown, A. S. ;

Sourander, A. ;

Hinkka-Yli-Salomaki, S. ;

McKeague, I. W. ;

Sundvall, J. ;

Surcel, H-M .

MOLECULAR PSYCHIATRY, 2014, 19 (02) :259-264

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