Serum Uric Acid Predicts All-Cause and Cardiovascular Mortality Independently of Hypertriglyceridemia in Cardiometabolic Patients without Established CV Disease: A Sub-Analysis of the URic acid Right for heArt Health (URRAH) Study

被引：17

作者：

Mengozzi, Alessandro ^{[1
,2
,3
]}

Pugliese, Nicola Riccardo ^{[1
]}

Desideri, Giovambattista ^{[4
]}

Masi, Stefano ^{[1
]}

Angeli, Fabio ^{[5
,6
]}

Barbagallo, Carlo Maria ^{[7
]}

Bombelli, Michele ^{[8
,11
]}

Cappelli, Federica ^{[1
]}

Casiglia, Edoardo ^{[9
]}

Cianci, Rosario ^{[10
]}

Ciccarelli, Michele

Cicero, Arrigo F. G. ^{[12
,13
,14
]}

Cirillo, Massimo ^{[15
]}

Cirillo, Pietro ^{[16
]}

Dell'Oro, Raffaella ^{[8
]}

D'Elia, Lanfranco

Ferri, Claudio ^{[4
]}

Galletti, Ferruccio ^{[17
]}

Gesualdo, Loreto ^{[14
]}

Giannattasio, Cristina ^{[18
,19
]}

Grassi, Guido ^{[8
]}

Iaccarino, Guido

Lippa, Luciano ^{[20
]}

Mallamaci, Francesca ^{[21
]}

Maloberti, Alessandro ^{[19
]}

Masulli, Maria

Mazza, Alberto ^{[22
]}

Muiesan, Maria Lorenza ^{[23
]}

Nazzaro, Pietro ^{[24
]}

Palatini, Paolo ^{[9
]}

Parati, Gianfranco ^{[25
,26
]}

Pontremoli, Roberto ^{[27
,28
]}

Quarti-Trevano, Fosca ^{[8
]}

Rattazzi, Marcello ^{[29
]}

Reboldi, Gianpaolo ^{[30
]}

Rivasi, Giulia ^{[31
]}

Russo, Elisa

Salvetti, Massimo

Tikhonoff, Valerie ^{[32
]}

Tocci, Giuliano ^{[33
]}

Ungar, Andrea ^{[31
]}

Verdecchia, Paolo ^{[34
]}

Viazzi, Francesca

Volpe, Massimo

Borghi, Claudio ^{[12
,13
,14
]}

Virdis, Agostino ^{[1
]}

机构：

[1] Univ Pisa, Dept Clin & Expt Med, I-56126 Pisa, Italy

[2] Univ Zurich, Univ Hosp Zurich, Ctr Translat & Expt Cardiol CTEC, Dept Cardiol, CH-8952 Schlieren, Switzerland

[3] Scuola Super Sant Anna, I-56127 Pisa, Italy

[4] Univ Laquila, Dept Life Hlth & Environm Sci, I-67100 Laquila, Italy

[5] Univ Insubria, Dept Med & Surg, I-21100 Varese, Italy

[6] IRCCS Tradate, Maugeri Care & Res Inst, Dept Med & Cardiopulm Rehabil, I-21100 Varese, Italy

[7] Univ Palermo, Biomed Dept Internal Med & Specialist, I-90100 Palermo, Italy

[8] Univ Milano Bicocca, Dept Med & Surg, Clin Med, I-20900 Monza, Italy

[9] Univ Padua, Dept Med, Studium Patavinum, I-35100 Padua, Italy

[10] Sapienza Univ Rome, Dept Translat & Precis Med, I-00185 Rome, Italy

[11] Federico II Univ Naples, Dept Adv Biomed Sci, I-80133 Naples, Italy

[12] Alma Mater Studiorum Univ Bologna, Dept Hypertens, I-40126 Bologna, Italy

[13] Alma Mater Studiorum Univ Bologna, Med & Surg Sci Dept, Cardiovasc Dis Res Ctr, I-40126 Bologna, Italy

[14] IRCCS AOU Bologna, Heart Chest Vasc Dept, I-40126 Bologna, Italy

[15] Federico II Univ Naples, Dept Publ Hlth, I-80133 Naples, Italy

[16] Aldo Moro Univ Bari, Dept Emergency & Organ Transplantat, Nephrol Dialysis & Transplantat Unit, I-70122 Bari, Italy

[17] Federico II Univ Naples, Dept Clin Med & Surg, I-80133 Naples, Italy

[18] Osped Niguarda Ca Granda, A De Gasperis Dept, Cardiol 4, I-20162 Milan, Italy

[19] Milano Bicocca Univ, Sch Med & Surg, I-20126 Milan, Italy

[20] Italian Soc Gen Med SIMG, I-67051 Avezzano, Italy

[21] CNR, Reggio Cal Unit, Clin Epidemiol Renal Dis & Hypertens, IFC, I-89124 Reggio Di Calabria, Italy

[22] Santa Maria Misericordia Gen Hosp, Dept Internal Med, AULSS Polesana 5, I-45100 Rovigo, Italy

[23] Univ Brescia, Dept Clin & Expt Sci, I-25121 Brescia, Italy

[24] Univ Bari, Dept Precis & Regenerat Med & Jonic Area DiMePRe, Neurosci & Sense Organs, Med Sch, I-70122 Bari, Italy

[25] S Luca Hosp, Ist Auxol Italiano, I-20126 Milan, Italy

[26] Univ Milano Bicocca, I-20126 Milan, Italy

[27] Univ Genoa, Dept Internal Med, I-16132 Genoa, Italy

[28] IRCSS Osped Policlin San Martino, I-16132 Genoa, Italy

[29] Univ Padua, Ca Foncello Univ Hosp, Dept Med DIMED, Med Interna 1, I-31100 Treviso, Italy

[30] Univ Perugia, Dept Med & Surg Sci, I-06100 Perugia, Italy

[31] Univ Florence, Careggi Hosp, Dept Geriatr & Intens Care Med, I-50121 Florence, Italy

[32] Univ Padua, Dept Med, I-35100 Padua, Italy

[33] Univ Rome Sapienza, Dept Clin & Mol Med, I-00185 Rome, Italy

[34] Hosp S Maria della Misericordia, I-06100 Perugia, Italy

来源：

METABOLITES | 2023年 / 13卷 / 02期

关键词：

serum uric acid; triglycerides; cardiovascular; risk prediction; mortality; cardiometabolic; hypertriglyceridemia; AGE; DYSFUNCTION; OBESITY; LEVEL;

D O I：

10.3390/metabo13020244

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

High serum uric acid (SUA) and triglyceride (TG) levels might promote high-cardiovascular risk phenotypes across the cardiometabolic spectrum. However, SUA predictive power in the presence of normal and high TG levels has never been investigated. We included 8124 patients from the URic acid Right for heArt Health (URRAH) study cohort who were followed for over 20 years and had no established cardiovascular disease or uncontrolled metabolic disease. All-cause mortality (ACM) and cardiovascular mortality (CVM) were explored by the Kaplan-Meier estimator and Cox multivariable regression, adopting recently defined SUA cut-offs for ACM (>= 4.7 mg/dL) and CVM (>= 5.6 mg/dL). Exploratory analysis across cardiometabolic subgroups and a sensitivity analysis using SUA/serum creatinine were performed as validation. SUA predicted ACM (HR 1.25 [1.12-1.40], p < 0.001) and CVM (1.31 [1.11-1.74], p < 0.001) in the whole study population, and according to TG strata: ACM in normotriglyceridemia (HR 1.26 [1.12-1.43], p < 0.001) and hypertriglyceridemia (1.31 [1.02-1.68], p = 0.033), and CVM in normotriglyceridemia (HR 1.46 [1.23-1.73], p < 0.001) and hypertriglyceridemia (HR 1.31 [0.99-1.64], p = 0.060). Exploratory and sensitivity analyses confirmed our findings, suggesting a substantial role of SUA in normotriglyceridemia and hypertriglyceridemia. In conclusion, we report that SUA can predict ACM and CVM in cardiometabolic patients without established cardiovascular disease, independent of TG levels.

引用

页数：15

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