Charting the Evolution of Chemoenzymatic Strategies in the Syntheses of Complex Natural Products

被引：24

作者：

Stout, Carter N. ^{[1
]}

Wasfy, Nour M. ^{[2
]}

Chen, Fang ^{[2
]}

Renata, Hans ^{[2
]}

机构：

[1] Scripps Res, Skaggs Doctoral Program Chem & Biol Sci, La Jolla, CA 92037 USA

[2] Rice Univ, Dept Chem, BioSci Res Collaborat, Houston, TX 77005 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2023年 / 145卷 / 33期

基金：

美国国家科学基金会;

关键词：

ENANTIOSELECTIVE TOTAL-SYNTHESIS; RAS FARNESYLATION INHIBITORS; DIELS-ALDER ADDUCTS; ASYMMETRIC HYDROGENATION; ISOPRENYLATED FLAVONOIDS; MICROBIAL OXIDATION; UNIDENTIFIED FUNGUS; DIVERGENT SYNTHESIS; DIRECTED EVOLUTION; PSEUDOMONAS-PUTIDA;

D O I：

10.1021/jacs.3c03422

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bolstered by recent advances in bioinformatics, genetics,and enzymeengineering, the field of chemoenzymatic synthesis has enjoyed a rapidincrease in popularity and utility. This Perspective explores theintegration of enzymes into multistep chemical syntheses, highlightingthe unique potential of biocatalytic transformations to streamlinethe synthesis of complex natural products. In particular, we identifyfour primary conceptual approaches to chemoenzymatic synthesis andillustrate each with a number of landmark case studies. Future opportunitiesand challenges are also discussed.

引用

页码：18161 / 18181

页数：21

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