Synthesis of 2-Heteroylidene Triterpenoids: Complex Formation with Palladium and in vitro Cytotoxic Activity

被引：3

作者：

Denisov, M. S. ^{[1
]}

机构：

[1] Russian Acad Sci, Perm Fed Res Ctr, Inst Tech Chem, Ural Branch, Perm 614013, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 01期

关键词：

triterpenoid; palladium(II) complex; cytotoxic activity; BETULONIC ACID; ANTICANCER;

D O I：

10.1134/S1070363223010061

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The interaction of palladium(II) chloride with 2-heteroylidene of betulonic acid (prepared via the condensation with pyridine-2-carbaldehyde, pyridine-3-carbaldehyde, pyridine-4-carbaldehyde, or quinoline-2-carbaldehyde) has been studied. Two ligands and one complex have been prepared for the first time; their structures have been confirmed by 2D NMR spectroscopy and high-resolution mass spectroscopy. The E-configuration of triterpenoid 2-heteroylidenes has been confirmed for the first time. Cytotoxic activity of the compounds with respect to the A549 cell line has been assessed.

引用

页码：37 / 42

页数：6

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