Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals

被引：57

作者：

Blum, Jonathan ^{[1
]}

Masjosthusmann, Stefan ^{[2
]}

Bartmann, Kristina ^{[2
]}

Bendt, Farina ^{[2
]}

Dolde, Xenia ^{[1
]}

Doenmez, Arif ^{[2
]}

Foerster, Nils ^{[4
]}

Holzer, Anna-Katharina ^{[1
]}

Huebenthal, Ulrike ^{[2
]}

Kessel, Hagen Eike ^{[2
]}

Kilic, Sadiye ^{[1
]}

Klose, Joerdis ^{[2
]}

Pahl, Melanie ^{[1
]}

Stuerzl, Lynn-Christin ^{[2
]}

Mangas, Iris ^{[5
]}

Terron, Andrea ^{[5
]}

Crofton, Kevin M. ^{[6
]}

Scholze, Martin ^{[7
]}

Mosig, Axel ^{[4
]}

Leist, Marcel ^{[1
]}

Fritsche, Ellen ^{[2
,3
]}

机构：

[1] Univ Konstanz, Doerenkamp Zbinden Fdn, In Vitro Toxicol & Biomed, D-78457 Constance, Germany

[2] IUF Leibniz Res Inst Environm Med, D-40225 Dusseldorf, Germany

[3] Heinrich Heine Univ, Med Fac, D-40225 Dusseldorf, Germany

[4] Ruhr Univ Bochum, Bioinformat Grp, D-44801 Bochum, Germany

[5] European Food Safety Author, PREV Unit, I-43126 Parma, Italy

[6] R3Fellows LLC, Durham, NC USA

[7] Brunel Univ London, Inst Environm Hlth & Soc, London, England

来源：

CHEMOSPHERE | 2023年 / 311卷

基金：

欧盟地平线“2020”;

关键词：

Testing battery; Stem cell; Brain development; In vitro testing; DNT; ALTERNATIVE METHODS; NEURITE OUTGROWTH; DNT; VALIDATION; IDENTIFY; ASSAY; NEURONS; MODEL; 21ST-CENTURY; CYTOTOXICITY;

D O I：

10.1016/j.chemosphere.2022.137035

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Developmental neurotoxicity (DNT) is a major safety concern for all chemicals of the human exposome. How-ever, DNT data from animal studies are available for only a small percentage of manufactured compounds. Test methods with a higher throughput than current regulatory guideline methods, and with improved human relevance are urgently needed. We therefore explored the feasibility of DNT hazard assessment based on new approach methods (NAMs). An in vitro battery (IVB) was assembled from ten individual NAMs that had been developed during the past years to probe effects of chemicals on various fundamental neurodevelopmental

引用

页数：17

共 117 条

[1] Glia as architects of central nervous system formation and function [J].

Allen, Nicola J. ;

Lyons, David A. .

SCIENCE, 2018, 362 (6411) :181-+

[2] Developing Context Appropriate Toxicity Testing Approaches Using New Alternative Methods (NAMs) [J].

Andersen, Melvin E. ;

McMullen, Patrick D. ;

Phillips, Martin B. ;

Yoon, Miyoung ;

Pendse, Salil N. ;

Clewell, Harvey J. ;

Hartman, Jessica K. ;

Moreau, Marjory ;

Becker, Richard A. ;

Clewell, Rebecca A. .

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 2019, 36 (04) :523-534

[3] Reference Compounds for Alternative Test Methods to Indicate Developmental Neurotoxicity (DNT) Potential of Chemicals: Example Lists and Criteria for their Selection and Use [J].

Aschner, Michael ;

Ceccatelli, Sandra ;

Daneshian, Mardas ;

Fritsche, Ellen ;

Hasiwa, Nina ;

Hartung, Thomas ;

Hogberg, Helena T. ;

Leist, Marcel ;

Li, Abby ;

Mundy, William R. ;

Padilla, Stephanie ;

Piersma, Aldert H. ;

Bal-Price, Anna ;

Seiler, Andrea ;

Westerink, Remco H. ;

Zimmer, Bastian ;

Lein, Pamela J. .

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 2017, 34 (01) :49-74

[4] Developmental Neurotoxicity of Environmentally Relevant Pharmaceuticals and Mixtures Thereof in a Zebrafish Embryo Behavioural Test [J].

Atzei, Alessandro ;

Jense, Ingrid ;

Zwart, Edwin P. ;

Legradi, Jessica ;

Venhuis, Bastiaan J. ;

van der Ven, Leo T. M. ;

Heusinkveld, Harm J. ;

Hessel, Ellen V. S. .

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2021, 18 (13)

[5] Recommendation on Test Readiness Criteria for New Approach Methods in Toxicology: Exemplified for Developmental Neurotoxicity [J].

Bal-Price, Anna ;

Hogberg, Helena T. ;

Crofton, Kevin M. ;

Daneshian, Mardas ;

FitzGerald, Rex E. ;

Fritsche, Ellen ;

Heinonen, Tuula ;

Bennekou, Susanne Hougaard ;

Klima, Stefanie ;

Piersma, Aldert H. ;

Sachana, Magdalini ;

Shafer, Timothy J. ;

Terron, Andrea ;

Monnet-Tschudi, Florianne ;

Viviani, Barbara ;

Waldmann, Tanja ;

Westerink, Remco H. S. ;

Wilks, Martin F. ;

Witters, Hilda ;

Zurich, Marie-Gabrielle ;

Leist, Marcel .

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 2018, 35 (03) :306-352

[6] International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes [J].

Bal-Price, Anna ;

Crofton, Kevin M. ;

Leist, Marcel ;

Allen, Sandra ;

Arand, Michael ;

Buetler, Timo ;

Delrue, Nathalie ;

FitzGerald, Rex E. ;

Hartung, Thomas ;

Heinonen, Tuula ;

Hogberg, Helena ;

Bennekou, Susanne Hougaard ;

Lichtensteiger, Walter ;

Oggier, Daniela ;

Paparella, Martin ;

Axelstad, Marta ;

Piersma, Aldert ;

Rached, Eva ;

Schilter, BenoIt ;

Schmuck, Gabriele ;

Stoppini, Luc ;

Tongiorgi, Enrico ;

Tiramani, Manuela ;

Monnet-Tschudi, Florianne ;

Wilks, Martin F. ;

Ylikomi, Timo ;

Fritsche, Ellen .

ARCHIVES OF TOXICOLOGY, 2015, 89 (02) :269-287

[7] Advancing the Science of Developmental Neurotoxicity (DNT): Testing for Better Safety Evaluation [J].

Bal-Price, Anna K. ;

Coecke, Sandra ;

Costa, Lucio ;

Crofton, Kevin M. ;

Fritsche, Ellen ;

Goldberg, Alan ;

Grandjean, Philippe ;

Lein, Pamela J. ;

Li, Abby ;

Lucchini, Roberto ;

Mundy, William R. ;

Padilla, Stephanie ;

Persico, Antonio M. ;

Seiler, Andrea E. M. ;

Kreysa, Joachim .

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 2012, 29 (02) :202-215

[8] Comparative human and rat neurospheres reveal species differences in chemical effects on neurodevelopmental key events [J].

Baumann, Jenny ;

Gassmann, Kathrin ;

Masjosthusmann, Stefan ;

DeBoer, Denise ;

Bendt, Farina ;

Giersiefer, Susanne ;

Fritsche, Ellen .

ARCHIVES OF TOXICOLOGY, 2016, 90 (06) :1415-1427

[9] Screening for Developmental Neurotoxicity at the National Toxicology Program: The Future Is Here [J].

Behl, Mamta ;

Ryan, Kristen ;

Hsieh, Jui-Hua ;

Parham, Frederick ;

Shapiro, Andrew J. ;

Collins, Bradley J. ;

Sipes, Nisha S. ;

Birnbaum, Linda S. ;

Bucher, John R. ;

Foster, Paul M. D. ;

Walker, Nigel J. ;

Paules, Richard S. ;

Tice, Raymond R. .

TOXICOLOGICAL SCIENCES, 2019, 167 (01) :6-14

[10] A Strategy for Comparing the Contributions of Environmental Chemicals and Other Risk Factors to Neurodevelopment of Children [J].

Bellinger, David C. .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2012, 120 (04) :501-507

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