In vitro-in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model

被引:7
作者
Pereira-da-Mota, Ana F. F. [1 ,2 ]
Vivero-Lopez, Maria [1 ,2 ]
Garg, Piyush [3 ]
Phan, Chau-Minh [3 ,4 ]
Concheiro, Angel [1 ,2 ]
Jones, Lyndon [3 ,4 ]
Alvarez-Lorenzo, Carmen [1 ,2 ]
机构
[1] Univ Santiago de Compostela, Fac Farm,Inst Mat iMATUS, Dept Farmacol Farm & Tecnol Farmaceut, I+D Farma Grp GI 1645, Santiago De Compostela 15782, Spain
[2] Univ Santiago de Compostela, Hlth Res Inst Santiago de Compostela IDIS, Santiago De Compostela 15782, Spain
[3] Univ Waterloo, Sch Optometry & Vis Sci, Ctr Ocular Res & Educ CORE, Waterloo, ON, Canada
[4] Ctr Eye & Vis Res CEVR, 17W,Hong Kong Sci Pk, Hong Kong, Peoples R China
基金
加拿大自然科学与工程研究理事会;
关键词
Drug-eluting contact lenses; Eye blink model; In vitro-in vivo correlations; Pravastatin sodium; Resveratrol; DELIVERY; RESVERATROL; SOLUBILITY; DESIGN;
D O I
10.1007/s13346-022-01276-6
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
There is still a paucity of information on how in vitro release profiles from drug-loaded contact lenses (CLs) recorded in 3D printed eye models correlate with in vivo profiles. This work aims to evaluate the release profiles of two drug-loaded CLs in a 3D in vitro eye blink model and compare the obtained results with the release in a vial and the drug levels in tear fluid previously obtained from an animal in vivo study. In vitro release in the eye model was tested at two different flow rates (5 and 10 mu L/min) and a blink speed of 1 blink/10 s. Model CLs were loaded with two different drugs, hydrophilic pravastatin and hydrophobic resveratrol. The release of both drugs was more sustained and lower in the 3D eye model compared to the in vitro release in vials. Interestingly, both drugs presented similar release patterns in the eye model and in vivo, although the total amount of drugs released in the eye model was significantly lower, especially for resveratrol. Strong correlations between percentages of pravastatin released in the eye model and in vivo were found. These findings suggest that the current 3D printed eye blink model could be a useful tool to measure the release of ophthalmic drugs from medicated CLs. Nevertheless, physiological parameters such as the composition of the tear fluid and eyeball surface, tear flow rates, and temperature should be optimized in further studies.
引用
收藏
页码:1116 / 1127
页数:12
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