Current developments in antibiotic discovery Global microbial diversity as a source for evolutionary optimized anti-bacterials

被引:27
作者
Hegemann, Julian D. [1 ,2 ]
Birkelbach, Joy [1 ,2 ]
Walesch, Sebastian [1 ,2 ]
Mueller, Rolf [1 ,2 ,3 ]
机构
[1] Helmholtz Ctr Infect Res HZI, Helmholtz Inst Pharmaceut Res Saarland HIPS, Saarbrucken, Germany
[2] Saarland Univ, Dept Pharm, Saarbrucken, Germany
[3] Helmholtz Int Lab Antiinfect, Saarbrucken, Germany
关键词
D O I
10.15252/embr.202256184
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In light of the pending antibiotic resistance crisis, we need to go back to nature and search for novel anti‐bacterial compounds.[graphic not available: see fulltext]
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页数:7
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共 16 条
  • [1] Engineering of Streptomyces lividans for heterologous expression of secondary metabolite gene clusters
    Ahmed, Yousra
    Rebets, Yuriy
    Estevez, Marta Rodriguez
    Zapp, Josef
    Myronovskyi, Maksym
    Luzhetskyy, Andriy
    [J]. MICROBIAL CELL FACTORIES, 2020, 19 (01)
  • [2] Cystobactamids: Myxobacterial Topoisomerase Inhibitors Exhibiting Potent Antibacterial Activity
    Baumann, Sascha
    Herrmann, Jennifer
    Raju, Ritesh
    Steinmetz, Heinrich
    Mohr, Kathrin I.
    Huettel, Stephan
    Harmrolfs, Kirsten
    Stadler, Marc
    Mueller, Rolf
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (52) : 14605 - 14609
  • [3] A Highly Polymorphic Receptor Governs Many Distinct Self-Recognition Types within the Myxococcales Order
    Cao, Pengbo
    Wei, Xueming
    Awal, Ram Prasad
    Mueller, Rolf
    Wall, Daniel
    [J]. MBIO, 2019, 10 (01):
  • [4] Expanded phylogeny of myxobacteria and evidence for cultivation of the 'unculturables'
    Garcia, Ronald
    Gerth, Klaus
    Stadler, Marc
    Dogma, Irineo J., Jr.
    Mueller, Rolf
    [J]. MOLECULAR PHYLOGENETICS AND EVOLUTION, 2010, 57 (02) : 878 - 887
  • [5] Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes
    Gavriilidou, Athina
    Kautsar, Satria A.
    Zaburannyi, Nestor
    Krug, Daniel
    Mueller, Rolf
    Medema, Marnix H.
    Ziemert, Nadine
    [J]. NATURE MICROBIOLOGY, 2022, 7 (05) : 726 - +
  • [6] Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria
    Hoffmann, Thomas
    Krug, Daniel
    Bozkurt, Nisa
    Duddela, Srikanth
    Jansen, Rolf
    Garcia, Ronald
    Gerth, Klaus
    Steinmetz, Heinrich
    Mueller, Rolf
    [J]. NATURE COMMUNICATIONS, 2018, 9
  • [7] Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus
    Kim, Sohn G.
    Becattini, Simone
    Moody, Thomas U.
    Shliaha, Pavel V.
    Littmann, Eric R.
    Seok, Ruth
    Gjonbalaj, Mergim
    Eaton, Vincent
    Fontana, Emily
    Amoretti, Luigi
    Wright, Roberta
    Caballero, Silvia
    Wang, Zhong-Min X.
    Jung, Hea-Jin
    Morjaria, Sejal M.
    Leiner, Ingrid M.
    Qin, Weige
    Ramos, Ruben J. J. F.
    Cross, Justin R.
    Narushima, Seiko
    Honda, Kenya
    Peled, Jonathan U.
    Hendrickson, Ronald C.
    Taur, Ying
    van den Brink, Marcel R. M.
    Pamer, Eric G.
    [J]. NATURE, 2019, 572 (7771) : 665 - +
  • [8] A new antibiotic kills pathogens without detectable resistance
    Ling, Losee L.
    Schneider, Tanja
    Peoples, Aaron J.
    Spoering, Amy L.
    Engels, Ina
    Conlon, Brian P.
    Mueller, Anna
    Schaeberle, Till F.
    Hughes, Dallas E.
    Epstein, Slava
    Jones, Michael
    Lazarides, Linos
    Steadman, Victoria A.
    Cohen, Douglas R.
    Felix, Cintia R.
    Fetterman, K. Ashley
    Millett, William P.
    Nitti, Anthony G.
    Zullo, Ashley M.
    Chen, Chao
    Lewis, Kim
    [J]. NATURE, 2015, 517 (7535) : 455 - +
  • [9] Scaling laws predict global microbial diversity
    Locey, Kenneth J.
    Lennon, Jay T.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (21) : 5970 - 5975
  • [10] Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
    Murray, Christopher J. L.
    Ikuta, Kevin Shunji
    Sharara, Fablina
    Swetschinski, Lucien
    Aguilar, Gisela Robles
    Gray, Authia
    Han, Chieh
    Bisignano, Catherine
    Rao, Puja
    Wool, Eve
    Johnson, Sarah C.
    Browne, Annie J.
    Chipeta, Michael Give
    Fell, Frederick
    Hackett, Sean
    Haines-Woodhouse, Georgina
    Hamadani, Bahar H. Kashef
    Kumaran, Emmanuelle A. P.
    McManigal, Barney
    Agarwal, Ramesh
    Akech, Samuel
    Albertson, Samuel
    Amuasi, John
    Andrews, Jason
    Aravkin, Aleskandr
    Ashley, Elizabeth
    Bailey, Freddie
    Baker, Stephen
    Basnyat, Buddha
    Bekker, Adrie
    Bender, Rose
    Bethou, Adhisivam
    Bielicki, Julia
    Boonkasidecha, Suppawat
    Bukosia, James
    Carvalheiro, Cristina
    Castaneda-Orjuela, Carlos
    Chansamouth, Vilada
    Chaurasia, Suman
    Chiurchiu, Sara
    Chowdhury, Fazle
    Cook, Aislinn J.
    Cooper, Ben
    Cressey, Tim R.
    Criollo-Mora, Elia
    Cunningham, Matthew
    Darboe, Saffiatou
    Day, Nicholas P. J.
    De Luca, Maia
    Dokova, Klara
    [J]. LANCET, 2022, 399 (10325) : 629 - 655