Two new eudesmane sesquiterpene glucosides from the aerial parts of Artemisia vulgaris

被引：5

作者：

Tran Thi Hong Hanh ^{[1
]}

Le Ba Vinh ^{[1
]}

Nguyen Xuan Cuong ^{[1
]}

Tran Hong Quang ^{[1
]}

机构：

[1] Vietnam Acad Sci & Technol VAST, Inst Marine Biochem IMBC, Hanoi, Vietnam

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 09期

关键词：

Artemisia vulgaris; Asteraceae; vulgaroside A; vulgaroside B; cytotoxic activity; LACTONES; LEAVES;

D O I：

10.1080/14786419.2022.2025591

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Using combined chromatographic methods, two new sesquiterpene glucosides, vulgarosides A (1) and B (2), and two known analogs ainsliaside E (3) and pumilaside A (4) were isolated from the aerial parts of Artemisia vulgaris. Their chemical structures were established by spectroscopic methods, including one and two-dimensional nuclear magnetic resonance (1 D and 2 D-NMR) spectroscopy and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). In addition, their cytotoxicity on five human cancer cell lines, including KB (epidermoid carcinoma), HepG2 (hepatocarcinoma), MCF7 (breast carcinoma), SK-Mel-2 (melanoma), and LNCaP (prostate cancer) was also evaluated by the SRB assay. However, none of the tested eudesmane sesquiterpene glycosides showed significant cytotoxicity (IC50>100 mu M).

引用

页码：1544 / 1549

页数：6

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