Synergistic vesicle-vector systems for targeted delivery

被引：11
作者：
Marquez, Christine Ardelle [1 ]
Oh, Cho-Im [1 ]
Ahn, Gna [1 ,2 ]
Shin, Woo-Ri [1 ,3 ]
Kim, Yang-Hoon [1 ,2 ]
Ahn, Ji-Young [1 ,2 ]
机构：
[1] Chungbuk Natl Univ, Dept Microbiol, 1 Chungdae Ro, Cheongju 28644, South Korea
[2] Chungbuk Natl Univ, Ctr Ecol & Environm Toxicol, Cheongju 28644, South Korea
[3] Univ Penn, Dept Bioengn, 210 S 33rd St, Philadelphia, PA 19104 USA
来源：
JOURNAL OF NANOBIOTECHNOLOGY | 2024年 / 22卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
Vesicle-vector system (VVS); Targeted delivery; Drug delivery system (DDS); Extracellular vesicle (EV); Liposome; Exosome; ACCELERATED BLOOD CLEARANCE; EXTRACELLULAR VESICLES; SURFACE DISPLAY; DRUG; LIPOSOMES; EXOSOMES; CELLS; APTAMER; NANOPARTICLES; PEPTIDE;
D O I：
10.1186/s12951-023-02275-6
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
With the immense progress in drug delivery systems (DDS) and the rise of nanotechnology, challenges such as target specificity remain. The vesicle-vector system (VVS) is a delivery system that uses lipid-based vesicles as vectors for a targeted drug delivery. When modified with target-probing materials, these vesicles become powerful vectors for drug delivery with high target specificity. In this review, we discuss three general types of VVS based on different modification strategies: (1) vesicle-probes; (2) vesicle-vesicles; and (3) genetically engineered vesicles. The synthesis of each VVS type and their corresponding properties that are advantageous for targeted drug delivery, are also highlighted. The applications, challenges, and limitations of VVS are briefly examined. Finally, we share a number of insights and perspectives regarding the future of VVS as a targeted drug delivery system at the nanoscale.
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页数：25
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