Serum albumin levels as a useful complementary marker for erectile dysfunction in ulcerative colitis: A cross-sectional study

被引：1

作者：

Yamamoto, Yasunori ^{[1
]}

Furukawa, Shinya ^{[2
]}

Miyake, Teruki ^{[3
]}

Yoshida, Osamu ^{[3
]}

Shiraishi, Kana ^{[3
]}

Hashimoto, Yu ^{[3
]}

Tange, Kazuhiro ^{[4
]}

Kitahata, Shogo ^{[5
]}

Ninomiya, Tomoyuki ^{[5
]}

Yagi, Sen ^{[6
]}

Hanayama, Masakazu ^{[7
]}

Suzuki, Seiyuu ^{[8
]}

Shibata, Naozumi ^{[9
]}

Murakami, Hidehiro ^{[10
]}

Ohashi, Katsuhisa ^{[11
]}

Tomida, Hideomi ^{[1
]}

Takeshita, Eiji ^{[4
]}

Ikeda, Yoshio ^{[1
]}

Hiasa, Yoichi ^{[3
]}

机构：

[1] Ehime Univ Hosp, Endoscopy Ctr, Toon, Ehime, Japan

[2] Ehime Univ, Hlth Serv Ctr, Bunkyo, Matsuyama, Ehime 7908577, Japan

[3] Ehime Univ, Grad Sch Med, Dept Gastroenterol & Metabol, Toon, Ehime, Japan

[4] Ehime Univ, Grad Sch Med, Dept Inflammatory Bowel Dis & Therapeut, Toon, Ehime, Japan

[5] Ehime Prefectural Cent Hosp, Dept Gastroenterol, Matsuyama, Ehime, Japan

[6] Saiseikai Imabari Hosp, Dept Internal Med, Imabari, Ehime, Japan

[7] Matsuyama Shimin Hosp, Dept Gastroenterol, Matsuyama, Ehime, Japan

[8] Sumitomo Besshi Hosp, Dept Gastroenterol, Niihama, Ehime, Japan

[9] Ehime Prefectural Niihama Hosp, Dept Pediat, Niihama, Ehime, Japan

[10] Saiseikai Matsuyama Hosp, Dept Internal Med, Matsuyama, Ehime, Japan

[11] OHASHI Clin Participate Gastro Enterol & Ano Proct, Niihama, Ehime, Japan

来源：

INTERNATIONAL JOURNAL OF UROLOGY | 2023年

关键词：

albumin; erectile dysfunction; sexual dysfunction; ulcerative colitis; INFLAMMATORY-BOWEL-DISEASE; RISK-FACTORS; PREVALENCE; MEN; SEVERITY;

D O I：

10.1111/iju.15327

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Recently, a close association between ulcerative colitis (UC) and erectile dysfunction (ED) was reported. An inverse relationship between serum albumin and ED is found in patients with chronic disease. However, the association between serum albumin levels and ED in patients with UC is unclear. This study aims to investigate this issue in Japanese patients with UC.Methods: One hundred and thirty-six Japanese male UC patients were enrolled in this study. Information on serum albumin levels and medications for UC from medical records, Sexual Health Inventory for Men (SHIM) score information from self-administered questionnaires and information on the severity of UC from physician reports were obtained from medical records, self-administered questionnaires, and reports from physicians. The participants were divided into tertiles based on the total protein, serum globulin, serum albumin, aspartate aminotransferase, and C-reactive protein levels. The definition of ED and severe ED was SHIM score < 22 and SHIM score < 8, respectively. The association between these serum markers and ED was assessed by multivariate logistic regression.Results: The prevalence of severe ED in the low, moderate, and high albumin groups was 66.0%, 51.0%, and 28.3%, respectively. After adjusting for confounding factors, the low albumin group was independently and positively associated with severe ED (adjusted odds ratio: 2.74, 95% confidence interval: 1.03-7.48, p for trend =0.044). No association between other marker and ED was found.Conclusion: Serum albumin was independently inversely associated with severe ED in Japanese patients with UC. Hypoalbuminemia might be a useful complementary marker for assessing the prevalence and severity of ED in UC patients.

引用

页码：154 / 159

页数：6

共 31 条

[1] Steroid-refractory ulcerative colitis: Predictive factors of response to cyclosporine and validation in an independent cohort [J].