Bactericidal activity of ZnO nanoparticles against multidrug-resistant bacteria

被引：24

作者：

Riahi, Sarra ^{[1
,4
]}

Ben Moussa, Nizar ^{[1
,2
]}

Lajnef, Mohamed ^{[2
]}

Jebari, Nessrine ^{[1
]}

Dabek, Ali ^{[2
]}

Chtourou, Radhouane ^{[2
]}

Guisbiers, Gregory ^{[3
]}

Vimont, Sophie ^{[4
,5
]}

Herth, Etienne ^{[1
]}

机构：

[1] Univ Paris Sud, Univ Paris Saclay, Ctr Nanosci & Nanotechnol, CNRS,UMR 9001, Palaiseau, France

[2] Univ Tunis El Manar, Fac Sci Tunis, Res & Technol Ctr Energy, Lab Nanomat & Syst Renewable Energies LaNSER, Technopark Borj Cedria,BP 095, Hammam Lif, Tunisia

[3] Univ Arkansas, Dept Phys & Astron, 2801 South Univ Ave, Little Rock, AR 72204 USA

[4] Sorbonne Univ, Hop St Antoine, AP HP, Dept Bacteriol, 184 Rue Fg St Antoine, F-75012 Paris, France

[5] Sorbonne Univ, Tenon Hosp, INSERM, UMRS 1155, 4 Rue Chine, F-75020 Paris, France

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2023年 / 387卷

关键词：

Zinc oxide nanoparticles; Drug delivery; Bacterial infection; Multidrug-resistant; MIC; MBC; ZINC-OXIDE NANOPARTICLES; ANTIBACTERIAL ACTIVITY; INFECTION; TOXICITY; METHICILLIN;

D O I：

10.1016/j.molliq.2023.122596

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Due to the massive use of antibiotics in agriculture, bacteria developed strategies to survive and this is causing the spread of Antibiotic Resistant Bacteria killing several hundred thousand people worldwide. In this paper, zinc oxide nanoparticles (ZnO NPs) synthesized by a sol-gel technique, are proposed as a potential solution against a variety of Gram-negative, Gram-positive and sensitive or multidrug-resistant (MDR) bacteria. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined. We found ZnO NPs were effective against Escherichia coli wild type, Escherichia coli producing carbapenemase (CRE), Klebsiella pneumoniae wild type, and Klebsiella pneumoniae producing Extended Spectrum Beta-lactamase (ESBL) wild type (SAT), Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-sensitive Staphylococcus aureus (MSSA).

引用

页数：8

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