Age as a modifier of the effects of sarcopenia on survival among colon cancer patients after surgery

被引：4
作者：
Lin, Wen-Li [1 ,2 ]
Wu, Li-Min [2 ,3 ,9 ]
Huang, Wen-Tsung [4 ,10 ]
Guo, How-Ran [5 ,6 ,8 ]
Chen, Jyh-Jou [7 ]
机构：
[1] Chi Mei Hosp, Ctr Qual Management, Tainan, Taiwan
[2] Kaohsiung Med Univ, Sch Nursing, Kaohsiung, Taiwan
[3] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan
[4] Chi Mei Hosp, Div Hematol & Oncol, Tainan, Taiwan
[5] Natl Cheng Kung Univ, Dept Environm & Occupat Hlth, Tainan, Taiwan
[6] Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med, Tainan, Taiwan
[7] Chi Mei Hosp, Div Gastroenterol & Hepatol, Tainan, Taiwan
[8] Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth, 138 Sheng-Li Rd, Tainan, Taiwan
[9] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Sch Nursing, Dept Med Res, Kaohsiung, Taiwan
[10] Chi Mei Med Ctr, Dept Internal Med, Div Hematol & Oncol, Tainan, Taiwan
来源：
JOURNAL OF SURGICAL ONCOLOGY | 2023年 / 128卷 / 07期
关键词：
age; colon cancer; recurrence rate; sarcopenia; survival; visceral adiposity; SKELETAL-MUSCLE MASS; INDEPENDENT PROGNOSTIC-FACTOR; CHARLSON COMORBIDITY INDEX; COLORECTAL-CANCER; POSTOPERATIVE OUTCOMES; VISCERAL ADIPOSITY; CLINICAL IMPACT; SOLID TUMORS; RESECTION; QUALITY;
D O I：
10.1002/jso.27405
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BackgroundStudies have been conducted to evaluate whether sarcopenia is a predictor for survival in patients with colon cancer postsurgery, but findings have been inconsistent, and effects of age were seldom evaluated. MethodsWe recruited 133 patients with resectable colon cancer who underwent surgery between January 2014 and December 2017 at a teaching hospital to evaluate the effects of sarcopenia on survival, after adjusting for age and other potential predictors, including visceral adiposity (VA). ResultsPreoperative sarcopenia was associated with worse overall survival (OS: 62.3% vs. 83.8%, p = 0.04) and longer hospital stay (20.6 vs. 14.9 days, p < 0.01) while VA was not. Cox proportional hazards regressions showed that sarcopenia was associated with an adjusted hazard ratio (HR) of 2.91 (95% confidence interval [CI]: 1.08-7.86) after adjustment for other independent risk factors, but was not associated with disease free survival. In stratified analyses, we found that sarcopenia was an independent factor for worse OS (adjusted HR = 1.94; 95% CI: 1.11-3.38) among patients >70 years, but not among patients & LE;70 years (HR = 0.48; 95% CI: 0.55-4.55). ConclusionsAge appeared to be a modifier of the effects of sarcopenia on OS among colon cancer patients postsurgery.
引用
收藏
页码：1121 / 1132
页数：12
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