Anti-citrullinated α-enolase peptide as a highly sensitive autoantigen in patients with rheumatoid arthritis

被引：1

作者：

Yeh, Fu-Chiang ^{[1
]}

Cherng, Juin-Hong ^{[2
,3
,4
]}

Chang, Shu-Jen ^{[3
]}

Huang, Wei-Ting ^{[4
]}

Chen, Hsiang-Cheng ^{[1
,5
]}

机构：

[1] Triserv Gen Hosp, Natl Def Med Ctr, Dept Med, Div Rheumatol Immunol Allergy, Taipei 114, Taiwan

[2] Grad Inst Life Sci, Natl Def Med Ctr, Taipei 114, Taiwan

[3] Natl Def Med Ctr, Dept & Grad Inst Biol & Anat, Taipei 114, Taiwan

[4] Chung Yuan Christian Univ, Dept Biomed Engn, Taoyuan 320, Taiwan

[5] Grad Inst Med Sci, Natl Def Med Ctr, Taipei 114, Taiwan

来源：

HELIYON | 2023年 / 9卷 / 12期

关键词：

Anti-citrullinated alpha-enolase peptide; Rheumatoid arthritis; Single nucleotide polymorphism; PROTEIN ANTIBODIES; DISEASE-ACTIVITY; SYNOVIAL-FLUID; RISK; ASSOCIATION; DIAGNOSIS; POPULATION;

D O I：

10.1016/j.heliyon.2023.e22745

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rheumatoid arthritis (RA) is the most common autoimmune rheumatic disease in Taiwan. Anticyclic citrullinated peptide (anti-CCP) assay is widely used for RA diagnosis; however, not all antiCCPs are detectable in RA-joint lesions. Citrullinated alpha-enolase peptide (CEP), which has a unique immunodominant epitope, can be detected in synovial fluid. Here, we aimed to evaluate the potential of anti-CEP as a serologic marker for the early diagnosis of RA and a prognostic predictor of joint destruction. We also determined the association of single-nucleotide polymorphisms (SNPs) in genes with the serological status and clinical characteristics of RA. Clinical records of 30 patients with RA were collected, and their serum and DNA samples were evaluated using enzyme-linked immunosorbent assay (ELISA) and SNP cross-reaction analysis. A considerable amount of anti-CEP was detected in patients with RA, a trend similar to that of anti-CCP. Moreover, anti-CEP was considerably associated with the protein-arginine deiminase type-2 SNP rs1005753.

引用

页数：10

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