Anti-citrullinated α-enolase peptide as a highly sensitive autoantigen in patients with rheumatoid arthritis

被引：1

作者：

Yeh, Fu-Chiang ^{[1
]}

Cherng, Juin-Hong ^{[2
,3
,4
]}

Chang, Shu-Jen ^{[3
]}

Huang, Wei-Ting ^{[4
]}

Chen, Hsiang-Cheng ^{[1
,5
]}

机构：

[1] Triserv Gen Hosp, Natl Def Med Ctr, Dept Med, Div Rheumatol Immunol Allergy, Taipei 114, Taiwan

[2] Grad Inst Life Sci, Natl Def Med Ctr, Taipei 114, Taiwan

[3] Natl Def Med Ctr, Dept & Grad Inst Biol & Anat, Taipei 114, Taiwan

[4] Chung Yuan Christian Univ, Dept Biomed Engn, Taoyuan 320, Taiwan

[5] Grad Inst Med Sci, Natl Def Med Ctr, Taipei 114, Taiwan

来源：

HELIYON | 2023年 / 9卷 / 12期

关键词：

Anti-citrullinated alpha-enolase peptide; Rheumatoid arthritis; Single nucleotide polymorphism; PROTEIN ANTIBODIES; DISEASE-ACTIVITY; SYNOVIAL-FLUID; RISK; ASSOCIATION; DIAGNOSIS; POPULATION;

D O I：

10.1016/j.heliyon.2023.e22745

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rheumatoid arthritis (RA) is the most common autoimmune rheumatic disease in Taiwan. Anticyclic citrullinated peptide (anti-CCP) assay is widely used for RA diagnosis; however, not all antiCCPs are detectable in RA-joint lesions. Citrullinated alpha-enolase peptide (CEP), which has a unique immunodominant epitope, can be detected in synovial fluid. Here, we aimed to evaluate the potential of anti-CEP as a serologic marker for the early diagnosis of RA and a prognostic predictor of joint destruction. We also determined the association of single-nucleotide polymorphisms (SNPs) in genes with the serological status and clinical characteristics of RA. Clinical records of 30 patients with RA were collected, and their serum and DNA samples were evaluated using enzyme-linked immunosorbent assay (ELISA) and SNP cross-reaction analysis. A considerable amount of anti-CEP was detected in patients with RA, a trend similar to that of anti-CCP. Moreover, anti-CEP was considerably associated with the protein-arginine deiminase type-2 SNP rs1005753.

引用

页数：10

共 50 条

[21] Associations of rheumatoid factor and anti-citrullinated peptide antibody with disease progression and treatment outcomes in patients with rheumatoid arthritis [J].

Katchamart, Wanruchada ;

Koolvisoot, Ajchara ;

Aromdee, Emvalee ;

Chiowchanwesawakit, Praveena ;

Muengchan, Chayawee .

RHEUMATOLOGY INTERNATIONAL, 2015, 35 (10) :1693-1699

[22] Progranulin-autoantibodies in sera of rheumatoid arthritis patients negative for rheumatoid factor and anti-citrullinated peptide antibodies [J].

Assmann, G. ;

Zinke, S. ;

Gerling, M. ;

Bittenbring, J. T. ;

Preuss, K. D. ;

Thurner, L. .

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2020, 38 (01) :94-98

[23] Anti-citrullinated protein/peptide antibodies (ACPA) in rheumatoid arthritis: Specificity and relation with rheumatoid factor [J].

Vander Cruyssen, B ;

Peene, I ;

Cantaert, T ;

Hoffman, IEA ;

De Rycke, L ;

Veys, EM ;

De Keyser, F .

AUTOIMMUNITY REVIEWS, 2005, 4 (07) :468-474

[24] Fine specificity of anti-citrullinated peptide antibodies discloses a heterogeneous antibody population in rheumatoid arthritis [J].

Goules, J. D. ;

Goules, A. V. ;

Tzioufas, A. G. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2013, 174 (01) :10-17

[25] Anti-Citrullinated Peptide/Protein Antibodies and Structural Prognosis of Rheumatoid Arthritis: Quantity Versus Quality [J].

Meyer, Olivier .

JOURNAL OF RHEUMATOLOGY, 2012, 39 (04) :675-676

[26] Serum Vitamin D and Anti-Cyclic Citrullinated Peptide Levels in Rheumatoid Arthritis Patients [J].

Mohamed, Esmael Faisal ;

Ibrahim, Altahir Saeed ;

Alkhatim, Mohammed Yassir ;

Mohammed, Layla Ahmed ;

Musa, Hassan Hussein ;

Idris, Alkhair Abd Almahmoud .

BIOMEDICAL RESEARCH AND THERAPY, 2022, 9 (07) :5149-5153

[27] Measurement and evaluation of isotypes of anti-citrullinated fibrinogen and anti-citrullinated alpha-enolase antibodies in juvenile idiopathic arthritis [J].

Moore, T. L. ;

Gilliam, B. E. ;

Crespo-Pagnussat, S. ;

Feller, L. ;

Chauhan, A. K. .

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2014, 32 (05) :740-746

[28] Diagnostic Utility of Anti-Citrullinated Protein Antibody and its Comparison with Rheumatoid Factor in Rheumatoid Arthritis [J].

Khan, Aysha Habib ;

Jafri, Lena ;

Hussain, M. Ahraz ;

Ishaq, Saliha .

JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN, 2012, 22 (11) :711-715

[29] Anti-citrullinated protein antibodies as biomarkers in rheumatoid arthritis [J].

Trier, Nicole Hartwig ;

Houen, Gunnar .

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023, :895-911

[30] Repeat serological testing for anti-citrullinated peptide antibody after commencement of therapy is not helpful in patients with seronegative rheumatoid arthritis [J].

Reid, Alistair B. ;

Wiese, Michael ;

McWilliams, Leah ;

Metcalf, Rob ;

Hall, Cindy ;

Lee, Anita ;

Hill, Catherine ;

Wechalekar, Mihir ;

Cleland, Les ;

Proudman, Susanna M. .

INTERNAL MEDICINE JOURNAL, 2020, 50 (07) :818-822

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