Synthesis of Manganese Zinc Ferrite Nanoparticles in Medical-Grade Silicone for MRI Applications

被引：11

作者：

Stoll, Joshua A. ^{[1
]}

Lachowicz, Dorota ^{[2
]}

Kmita, Angelika ^{[2
]}

Gajewska, Marta ^{[2
]}

Sikora, Marcin ^{[2
]}

Berent, Katarzyna ^{[2
]}

Przybylski, Marek ^{[2
]}

Russek, Stephen E. ^{[3
]}

Celinski, Zbigniew J. ^{[1
]}

Hankiewicz, Janusz H. ^{[1
]}

机构：

[1] Univ Colorado, Colorado Springs Ctr BioFrontiers Inst, 1420 Austin Bluffs Pkwy, Colorado Springs, CO 80918 USA

[2] AGH Univ Sci & Technol, Acad Ctr Mat & Nanotechnol, PL-30059 Krakow, Poland

[3] NIST, 325 Broadway St, Boulder, CO 80305 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 06期

基金：

美国国家科学基金会;

关键词：

silicone; ferrite; nanoparticles; NMR; MRI; MRI-guided surgery; MAGNETIC NANOPARTICLES; DEAGGLOMERATION; DEGRADATION; MECHANISMS; EFFICIENCY; ELASTOMER; DYNAMICS; NMR;

D O I：

10.3390/ijms24065685

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this project is to fabricate hydrogen-rich silicone doped with magnetic nanoparticles for use as a temperature change indicator in magnetic resonance imaging-guided (MRIg) thermal ablations. To avoid clustering, the particles of mixed MnZn ferrite were synthesized directly in a medical-grade silicone polymer solution. The particles were characterized by transmission electron microscopy, powder X-ray diffraction, soft X-ray absorption spectroscopy, vibrating sample magnetometry, temperature-dependent nuclear magnetic resonance relaxometry (20 degrees C to 60 degrees C, at 3.0 T), and magnetic resonance imaging (at 3.0 T). Synthesized nanoparticles were the size of 4.4 nm +/- 2.1 nm and exhibited superparamagnetic behavior. Bulk silicone material showed a good shape stability within the study's temperature range. Embedded nanoparticles did not influence spin-lattice relaxation, but they shorten the longer component of spin-spin nuclear relaxation times of silicone's protons. However, these protons exhibited an extremely high r(2)* relaxivity (above 1200 L s(-1) mmol(-1)) due to the presence of particles, with a moderate decrease in the magnetization with temperature. With an increased temperature decrease of r(2)*, this ferro-silicone can be potentially used as a temperature indicator in high-temperature MRIg ablations (40 degrees C to 60 degrees C).

引用

页数：15

共 67 条

[31] MODELLING PARTICLE DEAGGLOMERATION IN A BATCH HOMOGENIZER USING FULL CFD AND MECHANISTIC MODELS [J].

Krzosa, Radoslaw ;

Wojtas, Krzysztof ;

Golec, Jakub ;

Makowski, Lukasz ;

Orciuch, Wojciech ;

Adamek, Radoslaw .

CHEMICAL AND PROCESS ENGINEERING-NEW FRONTIERS, 2021, 42 (02) :105-118

[32] One-Step Preparation of Highly Stable Copper-Zinc FerriteNanoparticles in Water Suitable for MRI Thermometry [J].

Lachowicz, Dorota ;

Stroud, John ;

Hankiewicz, Janusz H. ;

Gassen, River ;

Kmita, Angelika ;

Stepien, Joanna ;

Celinski, Zbigniew ;

Sikora, Marcin ;

Zukrowski, Jan ;

Gajewska, Marta ;

Przybylski, Marek .

CHEMISTRY OF MATERIALS, 2022, 34 (09) :4001-4018

[33]

Lezzoni L., 1985, International Journal of Technology Assessment in Health Care, V1, P481, DOI DOI 10.1017/S0266462300001434

[34] Biomedical Silicones: Leveraging Additive Strategies to Propel Modern Utility [J].

Marmo, Alec C. ;

Grunlan, Melissa A. .

ACS MACRO LETTERS, 2023, 12 (02) :172-182

[35]

Martin T.D., 1994, Method 200.7 - determination of elements and trace elements in water and wastes by inductively coupled plasma-atomic emmission spectropmetry

[36]

McDannold N J, 2000, Top Magn Reson Imaging, V11, P191, DOI 10.1097/00002142-200006000-00005

[37] Towards optimized MRI contrast agents for implant engineering: Clustering and immobilization effects of magnetic nanoparticles [J].