Dual-mode strategy for 2,6-dipicolinic acid detection based on the fluorescence property and peroxidase-like activity inhibition of Fe-MIL-88NH2

被引：13
作者：
Deng, Donglian [1 ,2 ]
Xu, Jingyuan [1 ,2 ]
Li, Tingting [1 ,2 ]
Tan, Dongdong [1 ,2 ]
Ji, Yibing [1 ,2 ,3 ]
Li, Ruijun [1 ,2 ,3 ]
机构：
[1] China Pharmaceut Univ, Dept Analyt Chem, Nanjing 210009, Peoples R China
[2] Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China
[3] China Pharmaceut Univ, Dept Analyt Chem, 24 TongJiaXiang, Nanjing 210009, Jiangsu, Peoples R China
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2023年 / 291卷
基金：
中国国家自然科学基金;
关键词：
6-dipicolinic acid; Metal -organic framework; Nanozyme; Fluorometric; Colorimetric; METAL-ORGANIC FRAMEWORKS; DIPICOLINIC ACID; BACTERIA; DESIGN;
D O I：
10.1016/j.saa.2023.122363
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
This work designed a fluorometric/colorimetric dual-mode sensor for detecting 2,6-dipicolinic acid (DPA) based on the blue emission property and peroxidase-like activity of Fe-MIL-88NH2. The fluorescence of Fe-MIL-88NH2 was obviously turned off by Cu2+, but DPA was able to bring it back because it has a strong chelate bond with Cu2+. Fe-MIL-88NH2 also displayed high peroxidase-like activity, which accelerated the oxidation of 3,3 ',5,5 '- tetramethylbenzidine (TMB) to the blue oxidation product (oxTMB) when H2O2 was present. When DPA was added, it efficiently inhibited the peroxidase-like activity of Fe-MIL-88NH2, causing less oxTMB and less absorbance at 652 nm. The fluorescence recovery of Fe-MIL-88NH2 and the change in absorbance at 652 nm were used as analytical signals for dual-mode detection of DPA. The linear responses in the range of 10-60 mu M and 60-160 mu M were achieved for the fluorometric mode, and the limit of detection (LOD) was 1.46 mu M. The respective values of linear range and LOD for the colorimetric mode were 5-25 mu M and 3.00 mu M, respectively. In summary, the dual-mode testing strategy successfully detected DPA in aqueous environmental samples, sug-gesting great potential in disease prevention and environmental analysis.
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页数：8
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