Health-related quality of life in patients with steroid-refractory acute graft-versus-host disease

被引:0
作者
Leeneman, Brenda [1 ,2 ,6 ]
Blommestein, Hedwig M. [1 ,2 ]
van Dongen-Leunis, Annemieke [1 ,2 ]
Algeri, Mattia [3 ]
Fibbe, Willem E. [4 ]
Oosten, Liesbeth [5 ]
Uyl-de Groot, Carin A. [1 ,2 ]
Thielen, Frederick W. [1 ,2 ]
机构
[1] Erasmus Univ, Erasmus Sch Hlth Policy & Management, Dept Hlth Technol Assessment, Rotterdam, Netherlands
[2] Erasmus Univ, Erasmus Ctr Hlth Econ Rotterdam, Rotterdam, Netherlands
[3] Bambino Gesu Pediat Hosp, Dept Pediat Hematol & Oncol, Rome, Italy
[4] Leiden Univ, Dept Internal Med & Nephrol, Med Ctr, Leiden, Netherlands
[5] Leiden Univ, Dept Hematol, Med Ctr, Leiden, Netherlands
[6] Erasmus Univ, Erasmus Sch Hlth Policy & Management, Dept Hlth Technol Assessment, Rotterdam, Netherlands
基金
欧盟地平线“2020”;
关键词
EORTC QLQ-C30; EQ-5D-5L; FACT-BMT; graft-versus-host disease; health-related quality of life; patient-reported outcomes; EORTC QLQ-C30; POPULATION-SAMPLE; VALUES; EQ-5D-5L; SCORE;
D O I
10.1111/ejh.13987
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Evidence regarding health-related quality of life (HRQoL) in patients with steroid-refractory acute graft-versus-host disease (SR-aGvHD) is lacking. Evaluating HRQoL was a secondary objective of the HOVON 113 MSC trial. Here we describe the outcomes of the EQ-5D-5L, EORTC QLQ-C30, and FACT-BMT for all adult patients who completed these questionnaires at baseline (i.e., before the start of treatment; n = 26).Methods: Descriptive statistics were used to describe baseline patient and disease characteristics, EQ-5D dimension scores and values, EQ VAS scores, EORTC QLQ-C30 scale/item and summary scores, and FACT-BMT subscale and total scores.Results: The mean EQ-5D value was 0.36. In total, 96% of the patients reported problems with usual activities, 92% with pain/discomfort, 84% with mobility, 80% with self-care, and 72% with anxiety/depression. The mean EORTC QLQ-C30 summary score was 43.50. Mean scale/item scores ranged from 21.79 to 60.00 for functioning scales, from 39.74 to 75.21 for symptom scales, and from 5.33 to 91.67 for single items. The mean FACT-BMT total score was 75.31. Mean subscale scores ranged from 10.09 for physical well-being to 23.94 for social/family well-being.Conclusion: Our study showed that HRQoL in patients with SR-aGvHD is poor. Improving HRQoL and symptom management in these patients should be a top priority.
引用
收藏
页码:240 / 246
页数:7
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