α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect

被引：40

作者：

Liu, Huiyang ^{[1
,2
,3
,4
]}

Zhang, Xiaomei ^{[5
]}

Shi, Peng ^{[1
,2
,3
,4
]}

Yuan, Jiyuan ^{[6
]}

Jia, Qiang ^{[7
]}

Pi, Chao ^{[1
]}

Chen, Tao ^{[1
,2
,3
,4
]}

Xiong, Linjin ^{[1
,2
,3
,4
]}

Chen, Jinglin ^{[1
,2
,3
,4
]}

Tang, Jia ^{[1
,2
,3
,4
]}

Yue, Ruxu ^{[1
,2
,3
,4
]}

Liu, Zerong ^{[8
,9
]}

Shen, Hongping ^{[6
]}

Zuo, Ying ^{[10
]}

Wei, Yumeng ^{[3
]}

Zhao, Ling ^{[2
,3
,4
]}

机构：

[1] Southwest Med Univ, Key Lab Med Electrophysiol, Minist Educ, Sch Pharm, Luzhou 646000, Peoples R China

[2] Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Key Lab Med Electrophysiol, Minist Educ, 182 Chunhui Rd, Luzhou 646000, Sichuan, Peoples R China

[3] Southwest Med Univ, Cent Nervous Syst Drug Key Lab Sichuan Prov, Sch Pharm, Luzhou 646000, Sichuan, Peoples R China

[4] Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Luzhou Key Lab Tradit Chinese Med Chron Dis Jointl, Luzhou 646000, Sichuan, Peoples R China

[5] Chongqing Acad Chinese Mat Med, Inst Med Chem Chinese Med, Luzhou Key Lab Tradit Chinese Med Chron Dis Jointl, Chongqing 400065, Peoples R China

[6] Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Clin Trial Ctr, Luzhou 646000, Sichuan, Peoples R China

[7] Southwest Med Univ, Ethics Comm Off, Affiliated Tradit Chinese Med Hosp, Luzhou 646000, Sichuan, Peoples R China

[8] Sichuan Credit Pharmaceut CO Ltd, Cent Nervous Syst Drug Key Lab Sichuan Prov, Luzhou 646000, Sichuan, Peoples R China

[9] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400030, Peoples R China

[10] Southwest Med Univ, Dept Comprehens Med, Affiliated Tradit Chinese Med Hosp, 182 Chunhui Rd, Luzhou 646000, Sichuan, Peoples R China

来源：

JOURNAL OF NEUROINFLAMMATION | 2023年 / 20卷 / 01期

关键词：

Depression; Inflammation; alpha; 7; nAChR; POSITIVE ALLOSTERIC MODULATORS; MAJOR DEPRESSIVE DISORDER; SIGNALING PATHWAY; IN-VIVO; MITOCHONDRIAL DYSFUNCTION; SYSTEMIC INFLAMMATION; OXIDATIVE STRESS; CELL-SURVIVAL; VAGUS NERVE; MOUSE MODEL;

D O I：

10.1186/s12974-023-02768-z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Depression is a common mental illness, which is related to monoamine neurotransmitters and the dysfunction of the cholinergic, immune, glutamatergic, and neuroendocrine systems. The hypothesis of monoamine neurotransmitters is one of the commonly recognized pathogenic mechanisms of depression; however, the drugs designed based on this hypothesis have not achieved good clinical results. A recent study demonstrated that depression and inflammation were strongly correlated, and the activation of alpha7 nicotinic acetylcholine receptor (alpha 7 nAChR)-mediated cholinergic anti-inflammatory pathway (CAP) in the cholinergic system exhibited good therapeutic effects against depression. Therefore, anti-inflammation might be a potential direction for the treatment of depression. Moreover, it is also necessary to further reveal the key role of inflammation and alpha 7 nAChR in the pathogenesis of depression. This review focused on the correlations between inflammation and depression as well-discussed the crucial role of alpha 7 nAChR in the CAP.

引用

页数：19

共 240 条

[1] Targeting neuroinflammation by polyphenols: A promising therapeutic approach against inflammation-associated depression [J].

Abu Tayab, Mohammed ;

Islam, Mohammad Nazmul ;

Chowdhury, Kazi Ashfak Ahmed ;

Tasnim, Farhin Muntaha .

BIOMEDICINE & PHARMACOTHERAPY, 2022, 147

[2] Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders [J].

Adzic, Miroslav ;

Brkic, Zeljka ;

Bulajic, Sonja ;

Mitic, Milos ;

Radojcic, Marija B. .

DRUG DEVELOPMENT RESEARCH, 2016, 77 (07) :400-406

[3] Pathophysiological implications of neuroinflammation mediated HPA axis dysregulation in the prognosis of cancer and depression [J].

Ahmad, Mir Hilal ;

Rizvi, Moshahid Alam ;

Fatima, Mahino ;

Mondal, Amal Chandra .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2021, 520

[4] Nicotine strongly activates dendritic cell-mediated adaptive immunity - Potential role for progression of atherosclerotic lesions [J].

Aicher, A ;

Heeschen, C ;

Mohaupt, M ;

Cooke, JP ;

Zeiher, AM ;

Dimmeler, S .

CIRCULATION, 2003, 107 (04) :604-611

[5] Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression [J].

Allen, Josh ;

Romay-Tallon, Raquel ;

Brymer, Kyle J. ;

Caruncho, Hector J. ;

Kalynchuk, Lisa E. .

FRONTIERS IN NEUROSCIENCE, 2018, 12

[6] Alpha-7 nicotinic receptor allosteric modulator PNU120596 prevents lipopolysaccharide-induced anxiety, cognitive deficit and depression-like behaviors in mice [J].

Alzarea, Sami ;

Rahman, Shafiqur .

BEHAVIOURAL BRAIN RESEARCH, 2019, 366 :19-28

[7] Effects of alpha-7 nicotinic allosteric modulator PNU 120596 on depressive-like behavior after lipopolysaccharide administration in mice [J].

Alzarea, Sami ;

Rahman, Shafiqur .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2018, 86 :218-228

[8] Heterogeneity in HPA axis dysregulation and serotonergic vulnerability to depression [J].

Ancelin, Marie-Laure ;

Scali, Jacqueline ;

Norton, Joanna ;

Ritchie, Karen ;

Dupuy, Anne-Marie ;

Chaudieu, Isabelle ;

Ryan, Joanne .

PSYCHONEUROENDOCRINOLOGY, 2017, 77 :90-94

[9] Combined α7 nicotinic acetylcholine receptor agonism and partial serotonin transporter inhibition produce antidepressant-like effects in the mouse forced swim and tail suspension tests: A comparison of SSR180711 and PNU-282987 [J].

Andreasen, Jesper T. ;

Redrobe, John P. ;

Nielsen, Elsebet O. .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2012, 100 (03) :624-629

[10] Effects of intracellular calcium on cell survival and the MAPK pathway in a human hormone-dependent leukemia cell line (TF-1) [J].

Apáti, A ;

Jánossy, J ;

Brózik, A ;

Magócsi, M .

APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS, 2003, 1010 :70-73

← 1 2 3 4 5 6 7 8 9 10 →