Validity of Normative Volumetric Estimates from Open Access Software in Amnestic Mild Cognitive Impairment
被引:1
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Fountain-Zaragoza, S.
[1
]
Horn, O.
论文数: 0引用数: 0
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机构:
Med Univ South Carolina, Dept Neurol, Charleston, SC USAMed Univ South Carolina, Dept Hlth Sci & Res, Charleston, SC USA
Horn, O.
[2
]
Thorn, K. E.
论文数: 0引用数: 0
h-index: 0
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Med Univ South Carolina, Dept Neurol, Charleston, SC USAMed Univ South Carolina, Dept Hlth Sci & Res, Charleston, SC USA
Thorn, K. E.
[2
]
Kraal, A. Z.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Neurol, Irving Med Ctr, New York, NY USA
Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, Irving Med Ctr, New York, NY USAMed Univ South Carolina, Dept Hlth Sci & Res, Charleston, SC USA
Kraal, A. Z.
[3
,4
]
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Benitez, Andreana
[2
,5
]
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[1] Med Univ South Carolina, Dept Hlth Sci & Res, Charleston, SC USA
[2] Med Univ South Carolina, Dept Neurol, Charleston, SC USA
[3] Columbia Univ, Dept Neurol, Irving Med Ctr, New York, NY USA
[4] Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, Irving Med Ctr, New York, NY USA
[5] 96 Jonathan Lucas St, MSC 606, Charleston, SC 29425 USA
来源:
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
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2023年
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10卷
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02期
BackgroundNeurodegeneration in Alzheimer's disease (AD) is typically assessed through brain MRI. Although proprietary software can provide normative estimates of regional atrophy, such tools can be cost-prohibitive for research settings. Free software for generating normative estimates has recently been released but has yet to be validated in the context of amnestic mild cognitive impairment (aMCI).ObjectivesDetermine whether normative morphometric estimates generated from open-source software replicate established patterns of neurodegeneration in aMCI, and whether these metrics correlate with episodic memory performance.DesignObservational study of brain MRI and cognition in aging and aMCI with two identical study visits occurring approximately 1.2 years apart.SettingParticipants were recruited from the local community and outpatient clinical settings.ParticipantsAdults ages 60-85 with aMCI (n = 25) and cognitively normal controls (CN; n = 74). A subset returned for follow-up (aMCI n = 11, CN n = 52).MeasurementsParticipants completed brain MRI and two neuropsychological tests of verbal episodic memory. FreeSurfer v6.0 and Normative Morphometry Image Statistics were used to generate normative morphometric estimates for AD-relevant regions (hippocampus, parahippocampus, entorhinal cortex, amygdala) and control regions (cuneus, lingual gyrus, pericalcarine gyrus), adjusting for age, sex, head size, scanner manufacturer, and field strength. We tested for baseline group differences in ROI volumes and memory and assessed their within-group associations. We also evaluated changes in ROI volumes over time and tested whether these changes corresponded to declines in memory.ResultsAt baseline, the aMCI group exhibited poorer memory and smaller volumes in AD-relevant regions than the CN group. There were no group differences in control region volumes. Memory was associated with volumes in AD-relevant regions in the aMCI group only. The aMCI group exhibited greater declines than the CN group in hippocampal volume (17% vs. 8% annual decline) and entorhinal volume (54% vs. 5% annual decline). Decrease in hippocampal volume was marginally associated with decline in memory for the aMCI group.ConclusionsNormative morphometric values generated from freely available software demonstrated expected patterns of group differences in AD-related volumes and associations with memory. Significant effects were localized to AD-relevant brain regions and only occurred in the aMCI group. These findings support the validity of these free tools as reliable and cost-effective alternatives to proprietary software for use in research settings.
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Rush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USARush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA
Han, S. Duke
Suzuki, Hideo
论文数: 0引用数: 0
h-index: 0
机构:
Loyola Univ Chicago, Dept Biol, Chicago, IL USARush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA
Suzuki, Hideo
Jak, Amy J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Sch Med, Dept Psychiat, San Diego, CA 92103 USA
VA San Diego Healthcare Syst, Psychol Serv, San Diego, CA USARush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA
Jak, Amy J.
Chang, Yu-Ling
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Sch Med, Dept Psychiat, San Diego, CA 92103 USARush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA
Chang, Yu-Ling
Salmon, David P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Sch Med, Dept Neurosci, San Diego, CA 92103 USARush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA
Salmon, David P.
Bondi, Mark W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Sch Med, Dept Psychiat, San Diego, CA 92103 USA
VA San Diego Healthcare Syst, Psychol Serv, San Diego, CA USARush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA
机构:
Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
Nettiksimmons, Jasmine
DeCarli, Charles
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Davis, Dept Neurol, Sacramento, CA 95817 USA
Univ Calif Davis, Ctr Neurosci, Sacramento, CA 95817 USAUniv Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
DeCarli, Charles
Landau, Susan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USAUniv Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
Landau, Susan
Beckett, Laurel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Davis, Div Biostat, Dept Publ Hlth Sci, Davis, CA 95616 USAUniv Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
机构:
CogState Inc, New Haven, CT 06510 USACogState Inc, New Haven, CT 06510 USA
Harel, Brian T.
Darby, David
论文数: 0引用数: 0
h-index: 0
机构:
CogState Ltd, Melbourne, Vic, Australia
Univ Melbourne, Ctr Neurosci, Parkville, Vic 3052, AustraliaCogState Inc, New Haven, CT 06510 USA
Darby, David
Pietrzak, Robert H.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USACogState Inc, New Haven, CT 06510 USA
Pietrzak, Robert H.
Ellis, Kathryn A.
论文数: 0引用数: 0
h-index: 0
机构:
Mental Hlth Res Inst, Alzheimers Dis Clin Res Grp, Parkville, Vic, Australia
Univ Melbourne, Acad Unit Psychiat Old Age, Dept Psychiat, Kew, Vic, AustraliaCogState Inc, New Haven, CT 06510 USA
Ellis, Kathryn A.
Snyder, Peter J.
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Warren Alpert Med Sch, Dept Clin Neurosci, Providence, RI 02912 USA
Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06520 USACogState Inc, New Haven, CT 06510 USA
机构:
Sungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med, Seoul 06351, South KoreaSungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med, Seoul 06351, South Korea
Chun, Min Young
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Kim, Geon Ha
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Park, Hee Kyung
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Yang, Dong Won
Kim, SangYun
论文数: 0引用数: 0
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Seoul Natl Univ, Coll Med, Dept Neurol, Seongnam 13620, South Korea
Seoul Natl Univ, Bundang Hosp, Seongnam 13620, South KoreaSungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med, Seoul 06351, South Korea
Kim, SangYun
Choi, Seong Hye
论文数: 0引用数: 0
h-index: 0
机构:
Inha Univ, Dept Neurol, Sch Med, Inchon 22232, South KoreaSungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med, Seoul 06351, South Korea
Choi, Seong Hye
Jeong, Jee Hyang
论文数: 0引用数: 0
h-index: 0
机构:
Ewha Womans Univ, Coll Med, Dept Neurol, Seoul Hosp, Seoul 07804, South KoreaSungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med, Seoul 06351, South Korea
机构:
Rush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USARush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA
Han, S. Duke
Suzuki, Hideo
论文数: 0引用数: 0
h-index: 0
机构:
Loyola Univ Chicago, Dept Biol, Chicago, IL USARush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA
Suzuki, Hideo
Jak, Amy J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Sch Med, Dept Psychiat, San Diego, CA 92103 USA
VA San Diego Healthcare Syst, Psychol Serv, San Diego, CA USARush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA
Jak, Amy J.
Chang, Yu-Ling
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Sch Med, Dept Psychiat, San Diego, CA 92103 USARush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA
Chang, Yu-Ling
Salmon, David P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Sch Med, Dept Neurosci, San Diego, CA 92103 USARush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA
Salmon, David P.
Bondi, Mark W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Sch Med, Dept Psychiat, San Diego, CA 92103 USA
VA San Diego Healthcare Syst, Psychol Serv, San Diego, CA USARush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA
机构:
Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
Nettiksimmons, Jasmine
DeCarli, Charles
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Davis, Dept Neurol, Sacramento, CA 95817 USA
Univ Calif Davis, Ctr Neurosci, Sacramento, CA 95817 USAUniv Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
DeCarli, Charles
Landau, Susan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USAUniv Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
Landau, Susan
Beckett, Laurel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Davis, Div Biostat, Dept Publ Hlth Sci, Davis, CA 95616 USAUniv Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
机构:
CogState Inc, New Haven, CT 06510 USACogState Inc, New Haven, CT 06510 USA
Harel, Brian T.
Darby, David
论文数: 0引用数: 0
h-index: 0
机构:
CogState Ltd, Melbourne, Vic, Australia
Univ Melbourne, Ctr Neurosci, Parkville, Vic 3052, AustraliaCogState Inc, New Haven, CT 06510 USA
Darby, David
Pietrzak, Robert H.
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USACogState Inc, New Haven, CT 06510 USA
Pietrzak, Robert H.
Ellis, Kathryn A.
论文数: 0引用数: 0
h-index: 0
机构:
Mental Hlth Res Inst, Alzheimers Dis Clin Res Grp, Parkville, Vic, Australia
Univ Melbourne, Acad Unit Psychiat Old Age, Dept Psychiat, Kew, Vic, AustraliaCogState Inc, New Haven, CT 06510 USA
Ellis, Kathryn A.
Snyder, Peter J.
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Warren Alpert Med Sch, Dept Clin Neurosci, Providence, RI 02912 USA
Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06520 USACogState Inc, New Haven, CT 06510 USA
机构:
Sungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med, Seoul 06351, South KoreaSungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med, Seoul 06351, South Korea
Chun, Min Young
论文数: 引用数:
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机构:
Kim, Geon Ha
论文数: 引用数:
h-index:
机构:
Park, Hee Kyung
论文数: 引用数:
h-index:
机构:
Yang, Dong Won
Kim, SangYun
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Neurol, Seongnam 13620, South Korea
Seoul Natl Univ, Bundang Hosp, Seongnam 13620, South KoreaSungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med, Seoul 06351, South Korea
Kim, SangYun
Choi, Seong Hye
论文数: 0引用数: 0
h-index: 0
机构:
Inha Univ, Dept Neurol, Sch Med, Inchon 22232, South KoreaSungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med, Seoul 06351, South Korea
Choi, Seong Hye
Jeong, Jee Hyang
论文数: 0引用数: 0
h-index: 0
机构:
Ewha Womans Univ, Coll Med, Dept Neurol, Seoul Hosp, Seoul 07804, South KoreaSungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med, Seoul 06351, South Korea