Association between measured or calculated small dense low-density lipoprotein cholesterol and oxidized low-density lipoprotein in subjects with or without type 2 diabetes mellitus

被引:3
作者
Kim, Hyun-Ki [1 ]
Hong, Jinyoung [2 ,3 ]
Ahn, Sunyoung [4 ]
Lee, Woochang [2 ,3 ]
Chun, Sail [2 ,3 ]
Min, Won-Ki [2 ,3 ]
机构
[1] Univ Ulsan, Ulsan Univ Hosp, Dept Lab Med, Coll Med, Ulsan, South Korea
[2] Univ Ulsan, Coll Med, Dept Lab Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea
[3] Asan Med Ctr, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea
[4] Dong In Med Ctr, Dept Lab Med, Kangnung, South Korea
关键词
atherogenesis; diabetes mellitus; low-density lipoprotein; oxidized low-density lipoprotein; small dense low-density lipoprotein; CORONARY-HEART-DISEASE; LDL CHOLESTEROL; ANTIOXIDANT STATUS; RISK-FACTOR; SIZE; ERYTHROCYTES; SUBFRACTIONS; GLYCATION; ASSAY;
D O I
10.1002/jcla.24807
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
BackgroundSmall dense low-density lipoprotein (sdLDL) possesses atherogenic potential and is predicted to be susceptible to atherogenic modifications, which further increases its atherogenicity. However, studies on the association between measured or estimated sdLDL cholesterol (sdLDL-C) levels and atherogenic modification in diverse population groups are lacking. MethodsSurplus serum samples were collected from male subjects with type 2 diabetes mellitus (DM) under treatment (n = 300) and without DM (non-DM; n = 150). sdLDL and oxidized LDL (oxLDL) levels were measured using the Lipoprint LDL subfractions kit (Quantimetrix Corporation) and the Mercodia oxidized LDL competitive enzyme-linked immunosorbent assay kit (Mercodia), respectively. The estimated sdLDL-Cs were calculated from two relevant equations. The effects of sdLDL-C on oxLDL were assessed using multiple linear regression (MLR) models. ResultsThe mean (+/- SD) of measured sdLDL-C and oxLDL concentrations were 11.8 +/- 10.0 mg/dl and 53.4 +/- 14.2 U/L in the non-DM group and 0.20 +/- 0.81 mg/dl and 46.0 +/- 15.3 U/L in the DM group, respectively. The effects of measured sdLDL-Cs were significant (p = 0.031), whereas those of estimated sdLDL-Cs were not (p = 0.060, p = 0.116) in the non-DM group in the MLR models. The effects of sdLDL-Cs in the DM group were not significant. ConclusionIn the general population, high level of sdLDL-C appeared to be associated with high level of oxLDL. The equation for estimating sdLDL-C developed from a general population should be applied with caution to a special population, such as patients with DM on treatment.
引用
收藏
页数:8
相关论文
共 43 条
[41]   Glycation of LDL in non-diabetic people: Small dense LDL is preferentially glycated both in vivo and in vitro [J].
Younis, Nahla ;
Charlton-Menys, Valentine ;
Sharma, Reena ;
Soran, Handrean ;
Durrington, Paul N. .
ATHEROSCLEROSIS, 2009, 202 (01) :162-168
[42]   Small dense LDL is more susceptible to glycation than more buoyant LDL in Type 2 diabetes [J].
Younis, Nahla N. ;
Soran, Handrean ;
Pemberton, Philip ;
Charlton-Menys, Valentine ;
Elseweidy, Mohamed M. ;
Durrington, Paul N. .
CLINICAL SCIENCE, 2013, 124 (5-6) :343-349
[43]   Analysis of Lipoprotein Subfractions in 920 Patients With and Without Type 2 Diabetes [J].
Zhao, Xi ;
Zhang, Hui-Wen ;
Zhang, Yan ;
Li, Sha ;
Xu, Rui-Xia ;
Sun, Jing ;
Zhu, Cheng-Gang ;
Wu, Na-Qiong ;
Gao, Ying ;
Guo, Yuan-Lin ;
Liu, Geng ;
Dong, Qian ;
Li, Jian-Jun .
HEART LUNG AND CIRCULATION, 2017, 26 (03) :211-218