Comparison of the low-calorie DASH diet and a low-calorie diet on serum TMAO concentrations and gut microbiota composition of adults with overweight/obesity: a randomized control trial

被引：9

作者：

Diao, Zhipeng ^{[1
]}

Molludi, Jalall ^{[2
]}

Latef Fateh, Hawal ^{[3
,4
]}

Moradi, Sara ^{[2
]}

机构：

[1] Tianjin Yite Life Sci R&D Co LTD, Tianjin, Peoples R China

[2] Kermanshah Univ Med Sci, Res Ctr Environm Determinants Hlth RCEDH, Kermanshah, Iran

[3] Sulaimani Polytech Univ, Kalar Tech Coll, Nursing Dept, Sulaymaniyah, Iraq

[4] Garmian Polytech Univ, Kalar Tech Coll, Nursing Dept, Kalar, Iraq

来源：

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION | 2024年 / 75卷 / 02期

关键词：

Trimethylamine N-oxide; DASH diet; obesity; caloric restriction; cardiovascular disease risk factors; gut microbiome; lipopolysaccharides; TRIMETHYLAMINE-N-OXIDE; WEIGHT-LOSS; RISK-FACTORS; OBESITY; COMPLICATIONS; INFLAMMATION; SUPPLEMENTS; DISEASE;

D O I：

10.1080/09637486.2023.2294685

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

This study compares two diets, Dietary Approaches to Stop Hypertension (DASH) and a Low-Calorie Diet on Trimethylamine N-oxide (TMAO) levels and gut microbiota. 120 obese adults were randomly allocated to these three groups: a low-calorie DASH diet, a Low-Calorie diet, or a control group for 12 weeks. Outcomes included plasma TMAO, lipopolysaccharides (LPS), and gut microbiota profiles. After the intervention, the low-calorie DASH diet group demonstrated a greater decrease in TMAO levels (-20 +/- 8.1 vs. -10.63 +/- 4.6 mu M) and a significant decrease in LPS concentration (-19.76 +/- 4.2 vs. -5.68 +/- 2.3) compared to the low-calorie diet group. Furthermore, the low-calorie DASH diet showed a higher decrease in the Firmicutes and Bactericides (F/B) ratio, which influenced TMAO levels, compared to the Low-Calorie diet (p = 0.028). The current study found the low-calorie DASH diet improves TMAO and LPS in comparison to a Low-Calorie diet.

引用

页码：207 / 220

页数：14

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