SLCO1B1 variants and the risk of antituberculosis drug-induced hepatotoxicity: a systematic review and meta-analysis

被引：4

作者：

Zhu, Min ^{[1
]}

Chen, Xinyu ^{[1
]}

Hao, Zhuolu ^{[1
]}

He, Yiwen ^{[1
]}

Han, Bing ^{[1
]}

Tang, Shaowen ^{[1
]}

机构：

[1] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing 211166, Peoples R China

来源：

PHARMACOGENOMICS | 2023年 / 24卷 / 18期

基金：

中国国家自然科学基金;

关键词：

antituberculosis drug-induced hepatotoxicity; meta-analysis; single nucleotide polymorphism; INDUCED LIVER-INJURY; POLYMORPHISMS; TUBERCULOSIS; ASSOCIATION; GENE; SLCO1B1-ASTERISK-15; RIFAMPICIN; SLC10A1;

D O I：

10.2217/pgs-2023-0168

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aims: To evaluate the association between SLCO1B1 gene polymorphisms and susceptibility of antituberculosis drug-induced hepatotoxicity (ATDH). Methods: We searched the PubMed, Cochrane Library, Embase, Web of Science, Wan Fang and China National Knowledge Infrastructure database from inception to 2022. Results: Nine case-control studies with 1129 cases and 2203 controls were included. Among four SNPs reported in two or more studies, the final results indicated that SNP rs4149014 was significantly associated with decreased ATDH risk (dominant model, odds ratio: 0.73; 95% CI: 0.55-0.97; p = 0.03; allele model, odds ratio: 0.69; 95% CI: 0.55-0.86; p = 0.001), and the trial sequential analysis also confirmed this significant association. Conclusion: SLCO1B1 gene SNP rs4149014 was significantly associated with lower risk of ATDH susceptibility.

引用

页码：931 / 942

页数：12

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