ADME Prediction, Structure-activity Relationship of Boswellic Acid Scaffold for the Aspect of Anticancer & Anti-inflammatory Potency

被引：4

作者：

Kumar, Akhalesh ^{[1
]}

Sharma, Saurabh ^{[2
]}

Mishra, Sudhanshu ^{[3
]}

Ojha, Smriti ^{[3
]}

Upadhyay, Pawan ^{[1
]}

机构：

[1] Maharishi Univ Informat Technol, Dept Pharm, Lucknow, India

[2] Kalinga Univ, Fac Pharm, Raipur, India

[3] Madan Mohan Malaviya Univ Technol, Dept Pharmaceut Sci & Technol, Gorakhpur, India

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2023年 / 23卷 / 13期

关键词：

Natural remedies; SwissADME; boswellic acid; anti-inflammatory; anti-cancer; pentacyclic; SERRATA; APOPTOSIS; CELLS;

D O I：

10.2174/1871520623666230417080437

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nature is the chief source of various remedies which are used to cure various diseases. Boswellic acid (BA) is a secondary metabolite from the pentacyclic terpenoid compound groups that are derived from the plant genus Boswellia. The oleo gum resins of these plants are primarily composed of polysaccharides, with the remaining amounts of resin (30-60%) and essential oils (5-10%) soluble in organic solvents. BA and its analogs are also reported to exhibit various in vivo and biological responses for example anti-inflammatory, anti-tumor, free radical scavenging activity, etc. Among all analogs, 11-keto-& beta;-boswellic acid (KBA) and 3-O-acetyl-11-keto-& beta;-boswellic acid (AKBA) has been demonstrated to be the most effective at reducing cytokine production and inhibiting the inflammatory response-causing enzymes. In this review, we summarized the computational ADME prediction via the SwissADME computational tool and the structure-activity relationship of the Boswellic acid scaffold for the aspect of anticancer and anti-inflammatory potency. In addition to these research findings which are associated with the therapy of acute inflammation and some cancers, the potential of boswellic acids against other disorders was also discussed.

引用

页码：1499 / 1505

页数：7

共 33 条

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