Bile Cast Nephropathy Because of Acute Liver Injury Associated With Selective Androgen Receptor Modulators

被引：4

作者：

Arayangkool, Chinnawat ^{[1
]}

Gozun, Maan ^{[1
]}

Tanariyakul, Manasawee ^{[1
]}

Techasatian, Witina ^{[1
]}

Leesutipornchai, Thiratest ^{[1
]}

Nishimura, Yoshito ^{[1
]}

机构：

[1] Univ Hawaii, John A Burns Sch Med, Dept Med, Honolulu, HI 96822 USA

来源：

ACG CASE REPORTS JOURNAL | 2023年 / 10卷 / 07期

关键词：

selective androgen receptor modulator; bile cast nephropathy; drug-induced liver injury;

D O I：

10.14309/crj.0000000000001105

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Selective androgen receptor modulators (SARMs) are novel nonsteroidal agents abused for performance enhancement such as anabolic steroids. We report a case of a 27-year-old man who used 3 different SARMs and presented with progressive weakness. Initial laboratory testing showed kidney and liver injury with creatinine 4.8 mg/dL and total bilirubin 43.3 mg/dL. An extensive workup was negative for other causes, and the results of liver and kidney biopsies were consistent with bile cast nephropathy because of SARM-associated drug-induced liver injury. His organ functions improved with the cessation of SARMs and plasmapheresis. Providers need to recognize the extreme consequences of SARM use.

引用

页数：3

共 8 条

[1] Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports and literature review [J].

Koller, Tomas ;

Vrbova, Petra ;

Meciarova, Iveta ;

Molcan, Pavol ;

Smitka, Michal ;

Selcanova, Svetlana Adamcova ;

Skladany, Lubomir .

WORLD JOURNAL OF CLINICAL CASES, 2021, 9 (16) :4062-4071

[2]

Mohamed WT., 2023, CUREUS J MED SCIENCE, V15, pe35094

[3] Selective Androgen Receptor Modulators: An Emerging Liver Toxin [J].

Mohideen, Haseeb ;

Hussain, Hafsa ;

Dahiya, Dushyant Singh ;

Wehbe, Hisham .

JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2023, 11 (01) :188-196

[4] Detection of the selective androgen receptor modulator S-4 (Andarine) in a doping control sample [J].

Starcevic, Borislav ;

Ahrens, Brian D. ;

Butch, Anthony W. .

DRUG TESTING AND ANALYSIS, 2013, 5 (05) :377-379

[5] Recent advances in identifying and utilizing metabolites of selected doping agents in human sports drug testing [J].

Thevis, Mario ;

Piper, Thomas ;

Thomas, Andreas .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 205

[6] Bile cast nephropathy is a common pathologic finding for kidney injury associated with severe liver dysfunction [J].

van Slambrouck, Charles M. ;

Salem, Fadi ;

Meehan, Shane M. ;

Chang, Anthony .

KIDNEY INTERNATIONAL, 2013, 84 (01) :192-197

[7] Drug-Induced Liver Injury Secondary to Enobosarm: A Selective Androgen Receptor Modulator [J].

Weinblatt, Daniel ;

Roy, Satyajeet .

JOURNAL OF MEDICAL CASES, 2022, 13 (05) :244-248

[8] Herbal and dietary supplement induced liver injury: Highlights from the recent literature [J].

Woo, Stephanie M. ;

Davis, William D. ;

Aggarwal, Soorya ;

Clinton, Joseph W. ;

Kiparizoska, Sara ;

Lewis, James H. .

WORLD JOURNAL OF HEPATOLOGY, 2021, 13 (09) :1019-1041

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