sTREM-1 and TNF-α levels are associated with the clinical outcome of leprosy patients

被引：3

作者：

Bezerra-Santos, Marcio ^{[1
,2
,3
]}

Bomfim, Lays G. Santos ^{[2
,3
]}

Santos, Camilla N. Oliveira ^{[2
,3
]}

Cunha, Maria Wiliane N. ^{[2
]}

de Moraes, Eduardo J. Rocha ^{[2
]}

Cazzaniga, Rodrigo A. ^{[2
,3
]}

Tenorio, Martha D. L. ^{[3
,4
]}

Araujo, Jonnia M. Sherlock ^{[3
,4
]}

Menezes-Silva, Lucas ^{[2
]}

Magalhaes, Lucas Sousa ^{[2
,3
]}

Barreto, Aline S. ^{[2
,3
]}

Reed, Steven G. ^{[5
]}

Duthie, Malcolm S. ^{[5
]}

Lipscomb, Michael W. ^{[6
]}

de Almeida, Roque Pacheco ^{[2
,3
,7
,8
]}

de Moura, Tatiana Rodrigues ^{[2
,3
]}

de Jesus, Amelia Ribeiro ^{[2
,3
,7
,8
]}

机构：

[1] Univ Fed Alagoas, Ctr Ciencias Med & Enfermagem, Maceio, Brazil

[2] Univ Fed Sergipe, Lab Imunol & Biol Mol, Aracaju, Brazil

[3] Univ Fed Sergipe, Programa Posgrad Ciencias Saude, Aracaju, Brazil

[4] Univ Fed Sergipe, Hosp Univ, Dept Dermatol, Aracaju, Brazil

[5] Host Directed Therapeut HDT Bio Corp, Seattle, WA USA

[6] Univ Minnesota, Dept Pharmacol, Minneapolis, MN USA

[7] Univ Fed Sergipe, Dept Med, Aracaju, Brazil

[8] Conselho Nacl Pesquisa & Tecnol CNPq, Inst Invest Imunol 3, Inst Nacionais Ciencia & Tecnol INCTs, Sao Paulo, Brazil

来源：

FRONTIERS IN MEDICINE | 2023年 / 10卷

关键词：

leprosy; soluble TREM-1; inflammatory cytokine; immune markers; leprosy complications; GENE POLYMORPHISMS; MYELOID CELLS-1; TREM-1; SEPSIS; TLR;

D O I：

10.3389/fmed.2023.1177375

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Leprosy reaction (LR) and physical disability (PD) are the most significant clinical complications of leprosy. Herein, we assessed the circulating serum-sTREM-1 and TNF-& alpha; levels and their genetic polymorphisms in leprosy. Serum-sTREM-1 and TNF-& alpha; levels were measured in leprosy patients (LP) before treatment (n = 51) and from their household contacts (HHCs; n = 25). DNA samples were genotyped using TREM-1 rs2234246 and TNF-& alpha; rs1800629-SNP in 210 LPs and 168 endemic controls. The circulating sTREM-1 and TNF-& alpha; levels are higher in the multibacillary form. The ROC curve of the serum-sTREM-1 levels was able to differentiate LR from non-LR and PD from non-PD. Similarly, LPs with serum-sTREM-1 levels >210 pg/ml have 3-fold and 6-fold higher chances of presenting with LR and PD, respectively. Genotypes CC+CT of the TREM-1 were associated with leprosy. Taken together, our analyses indicated that sTREM-1 and TNF-& alpha; play an important role in the pathogenesis of leprosy and provide promising biomarkers to assist in the diagnosis of leprosy complications.

引用

页数：8

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